Evidence map›Paper›PMID 40407825›Full record

Observational studyEuropean journal of pediatrics2025

Serial lung ultrasound in predicting the need for surfactant and respiratory course in preterm infants-multicentre observational study (SLURP).

P K Loganathan, V Meau-Petit, B Bhojnagarwala, V Nair, J Holmes, A Occhipinti, M Montasser

Registry-linked trialAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in European journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05782569 (Serial Lung Ultrasound in Predicting the Need for Surfactant and Respiratory Course in Preterm Infants - Observational Study), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05782569 completednot on this map

Serial Lung Ultrasound in Predicting the Need for Surfactant and Respiratory Course in Preterm Infants - Observational Study (SLURP)

TypeobservationalSponsorSouth Tees Hospitals NHS Foundation TrustRan2023 to 2024Enrolled86ConditionsInfant, Premature
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

P K LoganathanNeonatal Unit, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK. pkannanloganathan@nhs.net.ORCID http://orcid.org/0000-0003-3717-8569
V Meau-PetitNeonatal and Paediatric Intensive Care Unit, Franco-Britannique Hospital, Levallois-Perret, France.
B BhojnagarwalaOliver Fisher Neonatal Unit, Medway NHS Foundation Trust, Kent, UK.
V NairNeonatal Unit, James Cook University Hospital, Marton Road, Middlesbrough, TS4 3BW, UK.
J HolmesSchool of Computing, Engineering and Digital Technologies, Teesside University, Middlesbrough, UK.
A OcchipintiSchool of Computing, Engineering and Digital Technologies, Teesside University, Middlesbrough, UK.
M MontasserNeonatal Unit, University Hospital Wishaw, Scotland, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung ultrasound (LUS) scores may predict surfactant need early and the progression of the respiratory course in preterm infants. The objective of this study is to report the diagnostic value of LUS scores performed by operators of varying levels of experience to predict the need for surfactant in preterm infants. A prospective observational study was conducted across 3 UK-based neonatal intensive care units. Preterm infants ≤ 34 weeks on non-invasive respiratory support within 3 h of birth were included. Ten lung zones were scored serially, first within the first 3 h of life, then at 12-24-h intervals (a total of four scans). All scans were performed by the local team members with formal training on LUS and varying levels of expertise. All the LUS videos were scored by an expert investigator who was blinded to clinical details. Written retrospective parental consents were obtained. We recruited 83 preterm infants ≤ 34 weeks (May 2023 to June 2024). A total of 325 LUS scans were performed by 27 clinical staff. The median birth gestational age and birth weight were 31 weeks and 1515 g, respectively. Twenty-eight (34%) babies received surfactants. The first LUS using a 6-zone method within 3 h of life predicted surfactant need and bronchopulmonary dysplasia with an AUC of 0.80 for both outcomes, offering sensitivity (79% and 73%) and specificity (75% and 76%), respectively.

conclusionsLUS performed by operators of varying levels of experience within the first 3 h of life is a reliable tool for predicting surfactant need in preterm infants ≤ 34 weeks.

trial registrationClinicalTrials.gov ( https://clinicaltrials.gov/ ): NCT05782569. WHAT IS KNOWN: • There are considerable variations in the selection criteria of preterm infants for surfactant administration. • Lung ultrasound score has been shown to predict the need for surfactant early and the progression of respiratory course in preterm infants. WHAT IS NEW: • LUS performed within 3 h of life by operators of varying levels of experience and interpreted by expert predicted the need for surfactant deficiency in preterm infants. • Our research with a structured training programme enabled novice operators to perform LUS and achieve reasonable competency.

Indexed as

LungPulmonary SurfactantsRespiratory Distress Syndrome, NewbornFemaleGestational AgeHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalMalePredictive Value of TestsProspective StudiesUltrasonographyPulmonary SurfactantsBronchopulmonary dysplasiaLung ultrasoundSurfactantTraining

Identifiers

PMID40407825
PMCPMC12102118

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.