Evidence map›Paper›PMID 40407756›Full record

ArticleThe Journal of organic chemistry2025

Diazacyclobutenes as Reactive Intermediates: The Cascade Cyclization of Thiolated Ene-ynes and Azodicarboxylates to Provide Tetrahydroindoles.

Samuel Kwain, Chandima J Narangoda, Brock A Miller, William DeSnoo, Monireh Noori, James W D Morris, Lauren Ulisse, Robert L Stevenson, Colin D McMillen, Rakesh Sachdeva and 2 more

Abstract read
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In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Samuel KwainDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Chandima J NarangodaDepartment of Chemistry, Faculty of Applied Sciences, University of Sri Jayewardenepura, Gangodawila, Nugegedo - 10250, Sri Lanka.
Brock A MillerDepartment of Chemistry, High Point University, High Point, North Carolina 27268, United States.
William DeSnooDepartment of Chemistry, University of California-Davis, Davis, California 95616, United States.
Monireh NooriDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
James W D MorrisDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Lauren UlisseDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Robert L StevensonDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Colin D McMillenDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Rakesh SachdevaDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.
Dean J TantilloDepartment of Chemistry, University of California-Davis, Davis, California 95616, United States.ORCID 0000-0002-2992-8844
Daniel C WhiteheadDepartment of Chemistry, Clemson University, Clemson, South Carolina 29634, United States.ORCID 0000-0001-6881-2628

Funding

Chemical synthesis to access rare heterocycles and tool compounds to probe bacterial polysaccharide metabolismR35GM153221 · NIGMS · CLEMSON UNIVERSITY · PI Daniel Charles Whitehead · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM153221
6 · The paper itself

Abstract

We describe a new one-pot synthesis to access richly functionalized tetrahydroindoles and related fused pyrroles. The key to this transformation is a robust cascade cyclization between ene-yne sulfides and azodicarboxylates involving diazacyclobutene formation primed for rapid electrocyclic ring opening to an α-iminothioimidate intermediate, followed by cyclization and aromatization to yield the

Identifiers

PMID40407756
PMCPMC13197856

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.