Evidence map›Paper›PMID 40407720›Full record

ArticleMagnetic resonance in medicine2025

Reassessment of peripheral nerve stimulation thresholds for the Impulse model-optimized asymmetric head gradient coil.

David A Feinberg, Samantha J Ma, Erica Walker, Alexander J S Beckett, Dominik Rattenbacher, Elmar Rummert, Peter Dietz, Mathias Davids, Nicolas Boulant

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

David A FeinbergDepartment of Neuroscience and Helen Wills Neuroscience Institute, Brain Imaging Center, University of California, Berkeley, California, USA.
Samantha J MaSiemens Medical Solutions, Malvern, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3127-455X
Erica WalkerDepartment of Neuroscience and Helen Wills Neuroscience Institute, Brain Imaging Center, University of California, Berkeley, California, USA.
Alexander J S BeckettDepartment of Neuroscience and Helen Wills Neuroscience Institute, Brain Imaging Center, University of California, Berkeley, California, USA.ORCID https://orcid.org/0000-0002-7123-9559
Dominik RattenbacherSiemens Healthcare, Erlangen, Germany.
Elmar RummertSiemens Healthcare, Erlangen, Germany.
Peter DietzSiemens Healthcare, Erlangen, Germany.
Mathias DavidsA.A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0217-9123
Nicolas BoulantDepartment of Neuroscience and Helen Wills Neuroscience Institute, Brain Imaging Center, University of California, Berkeley, California, USA.ORCID https://orcid.org/0000-0003-2144-2484

Funding

MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNERU01EB025162 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI FEINBERG, DAVID ALAN, LIU, CHUNLEI · 2017 to 2021
$13.4M
Training and Dissemination CoreP41EB030006 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Susie Yi Huang · 2020 to 2026
$10.9M
NexGen 7T MRI scanner for mesoscale brain imaging: Integration and DisseminationU24NS129949 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Alexander Beckett, David Alan Feinberg · 2023 to 2026
$5.3M
Highly Efficient MRI Pulse Sequences for High Resolution Physiological and Functional Brain ImagingR44MH129278 · NIMH · ADVANCED MRI TECHNOLOGY, LLC · PI BECKETT, ALEXANDER, FEINBERG, DAVID ALAN · 2021 to 2023
$4.3M
BRAIN Initiative U01-EB025162BRAIN Initiative U24-NS129949Horizon 2020 Framework Programme 885876NIBIB NIH HHS P41 EB030006NIBIB NIH HHS P41-EB030006NIBIB NIH HHS U01 EB025162NIMH NIH HHS R44 MH129278NIMH NIH HHS R44-MH129278NINDS NIH HHS U24 NS129949
6 · The paper itself

Abstract

purposePeripheral nerve stimulation (PNS) remains a physiologic limitation to boosting spatiotemporal resolution with more powerful gradients. We investigate discrepancies in previous measurements and model predictions from PNS experienced by volunteers scanned with the investigational "Impulse" gradient coil on the NexGen 7T scanner.

methodsTwenty-nine volunteers (18 males, mean ± standard deviation age 52.2 ± 17.1 years) underwent PNS characterizations in the scanner. The process was repeated after the subject positions were moved by 2 and 4 cm toward the feet, away from isocenter. These new data were compared with prior experimental data acquired at the factory (32 volunteers, 16 males, mean ± standard deviation age 58.3 ± 13.5 years) and to modeling results initially used to guide the gradient winding pattern.

resultsThe PNS threshold for the x-axis (left-right) was significantly below the threshold level predicted by the model used to optimize the wiring pattern and thresholds measured in the factory, whereas there was closer agreement for the y-axis (anterior-posterior) and z-axis (superior-inferior). The x-axis threshold increased as the subject was moved in the Z-direction toward the foot end of the magnet, at the expense of gradient nonlinearity distortions. Sensitivity of the threshold for the x-axis was measured as 20 mT/m per centimeter Z-offset.

conclusionThe PNS threshold of the x-axis measured in the scanner was much lower than predicted by the optimization model and as measured at the factory. Our measurements verified that PNS thresholds of asymmetric head gradient coils were sensitive to head position, subject variability, and age. The discrepancy of the PNS prediction model remains to be elucidated.

Indexed as

Magnetic Resonance ImagingPeripheral NervesAdultAgedElectric StimulationEquipment DesignFemaleHeadHumansMaleMiddle AgedReproducibility of ResultsSensitivity and Specificitybrain imaginghigh performance gradientmagneto‐stimulation thresholdsNexGen 7 Tperipheral nerve stimulation

Identifiers

PMID40407720
PMCPMC12202733

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.