Evidence map›Paper›PMID 40407620›Full record

ArticleRadiology. Imaging cancer2025

Prospective Evaluation of Contrast-enhanced Mammography for Early Prediction of Pathologic Response after Neoadjuvant Therapy.

Lígia Pires-Gonçalves, Ana Teresa Aguiar, Conceição Leal, António Guimarães-Santos, Miguel Abreu, Rui Henrique

Abstract read
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Article in Radiology. Imaging cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Lígia Pires-GonçalvesDepartment of Radiology and Cancer Biology and Epigenetics Group-Research Centre (CI-IPOP), Instituto Português de Oncologia do Porto (IPO-Porto), Francisco Gentil EPE, Rua António Bernardino de Almeida, 4200-072 Porto, Portugal.ORCID 0000-0002-5864-8526
Ana Teresa AguiarDepartment of Radiology, Instituto Português de Oncologia do Porto (IPO-Porto), Porto, Portugal.
Conceição LealDepartment of Pathology, Instituto Português de Oncologia do Porto (IPO-Porto), Porto, Portugal.
António Guimarães-SantosDepartment of Radiology, Instituto Português de Oncologia do Porto (IPO-Porto), Porto, Portugal.
Miguel AbreuDepartment of Medical Oncology, Instituto Português de Oncologia do Porto (IPO-Porto), Porto, Portugal.
Rui HenriqueDepartment of Radiology and Cancer Biology and Epigenetics Group-Research Centre (CI-IPOP), Instituto Português de Oncologia do Porto (IPO-Porto), Francisco Gentil EPE, Rua António Bernardino de Almeida, 4200-072 Porto, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose To assess whether changes in contrast-enhanced mammography (CEM)-derived lesion measurements after the first cycle of neoadjuvant therapy (NAT) can predict pathologic complete response (pCR) in individuals with breast cancer. Materials and Methods This prospective single-center pilot study enrolled consecutive participants with breast cancer treated with NAT who underwent CEM at baseline (May 2018 to December 2018). CEM was performed before and after the first cycle of NAT. Two breast radiologists independently evaluated the percentage change in the longest dimension of the lesion (CLD) and Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria at CEM. Multivariable logistic regression was used to identify independent predictors of pCR, and predictive performance was assessed using area under the receiver operating characteristic curve (AUC). Results Thirty-six participants (mean age ± SD, 48 years ± 10.3) were included; 11 (30.5%) participants achieved pCR. A CLD of at least 20.93% independently predicted pCR (odds ratio, 9.52; 95% CI: 1.34, 67.23;

Indexed as

Breast NeoplasmsContrast MediaMammographyNeoadjuvant TherapyAdultAgedFemaleHumansMiddle AgedPilot ProjectsPredictive Value of TestsProspective StudiesSensitivity and SpecificityContrast MediaBreastBreast TumorMammographyNeoadjuvant TherapyOncologyPathologic Complete ResponseRadiographic Image EnhancementTumor Response

Identifiers

PMID40407620
PMCPMC12130691

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.