Evidence map›Paper›PMID 40407521›Full record

ArticleInternational journal of neonatal screening2025

Newborn Screening for Congenital Heart Disease: A Five-Year Study in Shanghai.

Youping Tian, Qing Gu, Xiaojing Hu, Xiaoling Ge, Xiaojing Ma, Miao Yang, Pin Jia, Jing Zhang, Lulu Yang, Quming Zhao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of neonatal screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Youping TianNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.ORCID 0000-0003-1408-7306
Qing GuNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Xiaojing HuNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Xiaoling GeNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Xiaojing MaNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Miao YangNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Pin JiaNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Jing ZhangShanghai Center for Women and Children Health, Shanghai 200062, China.
Lulu YangShanghai Center for Women and Children Health, Shanghai 200062, China.
Quming ZhaoPediatric Heart Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Fang LiuPediatric Heart Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Ming YePediatric Heart Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.
Yulin YangShanghai Center for Women and Children Health, Shanghai 200062, China.
Guoying HuangNational Management Office of Neonatal Screening Project for Congenital Heart Disease, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai 201102, China.

Funding

Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences 2019-I2M-5-002National Key Research and Development Program of China 2016YFC1000500National Key Research and Development Program of China 2021YFC2701004National Natural Science Foundation of China 82270312Shanghai Health Commission of Health Industry Clinical Research Project 20234Y0211Shanghai Science and Technology Innovation Action Plan- Technical Standard Project 23DZ2203000Shanghai Science and Technology Innovation Action Plan- Technical Standard Project 24DZ2202800
6 · The paper itself

Abstract

This study aimed to report the progress and results of the newborn screening program for congenital heart disease (CHD) in south Shanghai between 2019 and 2023, and to evaluate the accuracy of the dual-index method (pulse oximetry (POX) plus cardiac murmur auscultation) in clinical practice. Between 2019 and 2023, a total of 198,606 (99.89%) newborns were screened for CHD, of whom 3299 (1.66%) tested positive, 3043 (92.24%) underwent echocardiography for CHD diagnosis and 1109 were diagnosed with CHD in a timely manner. Among 195,307 infants with negative screening results using the dual-index method, 139 (0.07%) were later diagnosed with CHD, and none of these infants died. More than half of these false-negative infants (59.39%) were identified due to the detection of a heart murmur during routine physical examinations within six months after birth. Compared to POX testing alone, the dual-index method significantly improved the sensitivity of screening for CHD, and kept high specificity in clinical practice. This study demonstrated that newborn screening for CHD has been well conducted in Shanghai, and the dual-index method had high accuracy and reliability for neonatal CHD screening in clinical practice.

Indexed as

congenital heart diseasedual-index methodnewborn screeningShanghai

Identifiers

PMID40407521
PMCPMC12101202

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.