Evidence map›Paper›PMID 40407520›Full record

ArticleInternational journal of neonatal screening2025

Screening Blind Spot: Missing Preterm Infants in the Detection of Congenital Hypothyroidism.

Ashleigh Brown, Paul Hofman, Dianne Webster, Natasha Heather

Abstract read
In one paragraph

Article in International journal of neonatal screening, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ashleigh BrownStarship Child Health, Te Whatu Ora Te Toka Tumai Auckland, Auckland 1023, New Zealand.ORCID 0009-0008-5638-1558
Paul HofmanStarship Child Health, Te Whatu Ora Te Toka Tumai Auckland, Auckland 1023, New Zealand.
Dianne WebsterLiggins Institute, University of Auckland, Auckland 1023, New Zealand.
Natasha HeatherStarship Child Health, Te Whatu Ora Te Toka Tumai Auckland, Auckland 1023, New Zealand.ORCID 0000-0003-2895-3279

Funding

Starship Foundation Fellowship N/A
6 · The paper itself

Abstract

Congenital hypothyroidism (CH) is a critical condition in infancy where early detection is vital for optimal development. This study aimed to evaluate the sensitivity of Aotearoa New Zealand's Newborn Metabolic Screening "Low Birth Weight" protocol for detecting CH in preterm infants. A 10-year audit was conducted on 2935 preterm infants (<2000 g or ≤34 weeks gestation) screened within NICUs or SCBUs in the Auckland region. The study assessed both screen-detected and clinically detected cases of CH. Data were collected from screening and clinical records to evaluate the sensitivity and reliability of the current protocol. The audit identified 19 cases of primary CH, with a 1:154 incidence. Thirteen cases met the criteria for inclusion in the audit. Just over half of the eligible cases (7/13) were screen-detected, while the remaining were detected clinically, suggesting limitations in screening sensitivity. The analysis revealed that the protocol missed permanent as well as transient cases, and that biochemical severity was not predictive of permanence. A revised screening protocol was developed and commenced in July 2024.

Indexed as

congenital hypothyroidismlow birth weightnewborn screeningpretermscreening

Identifiers

PMID40407520
PMCPMC12101188

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.