Evidence map›Paper›PMID 40407324›Full record

ArticlemBio2025

TcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen

Joshua Carlson, Milad Ahmed, Riley Hunter, Syeda Farjana Hoque, Joshua B Benoit, Miguel A Chiurillo, Noelia Lander

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Cloning-Free Genome Editing by CRISPR/T7RNAP/Cas9 in Trypanosoma cruzi.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Joshua CarlsonDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Milad AhmedDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Riley HunterDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Syeda Farjana HoqueDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Joshua B BenoitDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-4018-3513
Miguel A ChiurilloDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-5581-9027
Noelia LanderDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0003-2178-381X

Funding

Large-scale CRISPR screening of essential calcium-related genes in the human parasite Tr. cruziR00AI137322 · NIAID · UNIVERSITY OF CINCINNATI · PI LANDER, NOELIA · 2021 to 2022
$498k
Barcode screening of essential protein kinases in the life cycle progression of Trypanosoma cruziR21AI178573 · NIAID · UNIVERSITY OF CINCINNATI · PI CHIURILLO, MIGUEL A · 2023 to 2024
$446k
National Institute of Allergy and Infectious Diseases R00AI137322National Institute of Allergy and Infectious Diseases R21AI178573NIAID NIH HHS R00 AI137322NIAID NIH HHS R21 AI178573
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cyclic AMPOsmoregulationProtozoan ProteinsTrypanosoma cruziAdenylyl CyclasesAnimalsChagas DiseaseHumansInsect VectorsLife Cycle StagesSignal TransductionAdenylyl CyclasesCyclic AMPProtozoan Proteinsadenylate cyclaseChagas diseasecontractile vacuole complexflagellar distal domainkissing bugsmetacyclogenesisregulatory volume decreasetrypanosomes

Identifiers

PMID40407324
PMCPMC12153354

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.