ArticleChemPlusChem2025
Unveiling the Decarboxylation of a Malonic Acid-Containing Macrocycle at Acidic pH: Implications and Applications of an Overlooked Phenomenon.
Article in ChemPlusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
1,10-Diaza-18-crown-6-1,10-bis(malonic acid) (oddm or macromal) is a promising chelator for large hard metal cations due to its unique structure, which combines the complexing properties of aza-crown Kryptofix 22 with those of malonic acid. This study uncovers the previously overlooked decarboxylation of macromal under mildly to strongly acidic pH conditions at room temperature. As a result, the acidity constants of macromal are carefully re-evaluated, providing precise data for its accurate and informed handling in aqueous media. The implications of these findings for metal complexation and new possible applications of macromal are also presented.
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