ArticleDialogues in clinical neuroscience2025
Cyberdelics: Virtual reality hallucinations modulate cognitive-affective processes.
Article in Dialogues in clinical neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Virtual reality and psychedelics: new perspectives and new possibilities in the treatment of alcohol use disorder.Frontiers in psychiatry · 2025Review
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11 authors.
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Abstract
introductionPsychedelics were explored for their potential in the mental health field. However, research was delayed by concerns over short-term side effects and long-term consequences of substance use. Technological advances enabled the development of Hallucinatory Visual Virtual Experiences (HVVEs), namely psychedelic experiences simulations in immersive virtual reality. This study investigated HVVEs' impact on cognitive flexibility, affective response, and autonomic activity.
methods50 healthy participants underwent assessments of cognitive flexibility, control inhibition, emotional response, and autonomic activity at baseline. Participants were then exposed to two 10-minute immersive virtual reality (IVR) experiences: 'The Secret Garden' and its hallucinated counterpart created using Google DeepDream algorithm. All measures were presented after each video, in addition to the flow experience assessment.
resultsPost-HVVE, participants demonstrated enhanced cognitive flexibility and inhibitory control. They reported increased flow-absorption and decreased flow-fluency. Both IVR experiences reduced positive affects and state anxiety compared to baseline; additionally, IVR reduced heart rate and sympathetic activity compared to baseline.
conclusionsHVVEs produced psychedelic positive effects on cognitive and emotional functioning. The complex emotional and autonomic profile mimicked awakened relaxation that, in conjunction with the cognitive flexibility enhancement, could offer the unique opportunity to exploit psychedelic advantages while mitigating risks, opening new avenues for therapeutic approaches.
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