Evidence map›Paper›PMID 40407244›Full record

ArticleACS infectious diseases2025

Bumped Kinase Inhibitors Inhibit both

Jemma A Montgomery, P Holland Alday, Ryan Choi, Monique Khim, Bart L Staker, Matthew A Hulverson, Kayode K Ojo, Erkang Fan, Wesley C Van Voorhis, J Stone Doggett

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Discovery of novel anti-RSC advances · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Microorganisms · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jemma A MontgomeryDivision of Infectious Diseases, Portland VA Medical Center, Portland, Oregon 97239, United States.ORCID 0009-0006-0371-9071
P Holland AldayDivision of Infectious Diseases, Portland VA Medical Center, Portland, Oregon 97239, United States.ORCID 0000-0002-0142-2438
Ryan ChoiCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98109, United States.
Monique KhimSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.
Bart L StakerSeattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington 98109, United States.ORCID 0000-0001-9570-5086
Matthew A HulversonCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98109, United States.ORCID 0000-0002-3413-4969
Kayode K OjoCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98109, United States.
Erkang FanDepartment of Biochemistry, University of Washington, Seattle, Washington 98109, United States.
Wesley C Van VoorhisCenter for Emerging and Re-emerging Infectious Diseases (CERID), Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98109, United States.ORCID 0000-0001-6141-2015
J Stone DoggettDivision of Infectious Diseases, Portland VA Medical Center, Portland, Oregon 97239, United States.ORCID 0000-0002-6098-1520

Funding

Centers for Research on Structural Biology of Infectious Diseases: Universal Influenza Vaccine Research75N93022C00036 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI STAKER, BART · 2022 to 2025
$21.7M
ChimeraX -- Next Generation Visualization and Analysis Software for Multiscale ModelingR01GM129325 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2018 to 2025
$5.2M
Bumped-Kinase Inhibitor Drug Development for ToxoplasmosisR01HD102487 · NICHD · UNIVERSITY OF WASHINGTON · PI VAN VOORHIS, WESLEY C · 2021 to 2025
$3.3M
BLRD VA I01 BX004522NIAID NIH HHS 75N93022C00036NICHD NIH HHS R01 HD102487NIGMS NIH HHS R01 GM129325NIH HHS 75N93022C00036
6 · The paper itself

Abstract

A subset of bumped kinase inhibitors (BKIs) has been optimized to inhibit the calcium dependent protein kinase 1 (

Indexed as

Protein Kinase InhibitorsProtein KinasesProtozoan ProteinsToxoplasmaCalcium-Calmodulin-Dependent Protein KinasesDrug ResistanceHumansCalcium-Calmodulin-Dependent Protein KinasesProtein Kinase InhibitorsProtein KinasesProtozoan Proteinsantiparasitic drugsbumped kinase inhibitordrug mechanismkinasetherapeuticstoxoplasmosis

Identifiers

PMID40407244
PMCPMC12172689

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.