Evidence map›Paper›PMID 40407205›Full record

ArticleSexually transmitted diseases2025

Syphilis Screening and Treatment at a Large Urban Jail.

Zureyat Sola-Odeseye, Jana Kholy, Sophia Culp, Barry-Lewis Harris, Ank E Nijhawan

Abstract read
In one paragraph

Article in Sexually transmitted diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zureyat Sola-OdeseyeFrom the University of Texas Southwestern Medical School.ORCID 0000-0002-2565-1972
Jana KholyFrom the University of Texas Southwestern Medical School.
Sophia CulpParkland Health, Correctional Health.
Barry-Lewis HarrisParkland Health, Correctional Health.
Ank E NijhawanDepartment of Internal Medicine, Division of Infectious Diseases and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0000-0003-0522-4110

Funding

Trends in Incidence and Prevalence of HIV Diagnoses in a Jail Population in the Southern United StatesR01MH129185 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI Douglas Scott Krakower, Ank Elisabeth Nijhawan · 2022 to 2026
$3.2M
NIMH NIH HHS R01 MH129185
6 · The paper itself

Abstract

backgroundSyphilis cases have increased by 80% in the United States in the past 5 years, demanding new approaches to screening and treatment, particularly among key populations. This study aimed to assess the impact of syphilis screening in a large urban county jail, determining rates of new syphilis infections, identifying demographic groups most affected by syphilis, and assessing treatment completion rates.

methodsElectronic health records of individuals with positive rapid plasma reagin (RPR) results during incarceration in the Dallas County Jail between April 2023 and March 2024 were reviewed. New cases were defined by either a first positive RPR, a 4-fold titer increase, or a positive result after a previously negative RPR. Data on demographics, HIV coinfection, and recent chlamydia or gonorrhea infection were collected. Treatment medication and completion (no, partial, or full) were recorded. Comparisons of proportions were performed using χ2 analysis, and data analyses were conducted using SAS OnDemand for Academics (SAS 9.4 M8).

resultsOf 15,589 individuals tested for syphilis, 12,607 (80.9%) were male and 2982 (19.1%) were female. Among these, there were 1816 (11.6%) cases of positive test results; 815 individuals (5.2%) were newly diagnosed with syphilis: 568 males (4.5%) and 247 females (8.3%). Among those newly diagnosed, most (71.2%) were treated with doxycycline. Overall, 482 individuals (59.1%) completed treatment, 191 (23.4%) received partial treatment, and 142 (17.4%) were released before receiving any treatment.

conclusionsSyphilis screening in a large urban jail identified high rates of new infections and provided an opportunity for counseling, testing for other STIs and treatment. Females and African Americans had disproportionately high infection rates. Treatment completion was similar between doxycycline and intramuscular penicillin. Future studies should focus on increasing syphilis screening, treatment, and prevention in jails and other high-incidence settings.

Indexed as

JailsMass ScreeningPrisonsSyphilisAdultAnti-Bacterial AgentsFemaleGonorrheaHIV InfectionsHumansMaleMiddle AgedPrisonersRetrospective StudiesSyphilis SerodiagnosisUrban PopulationAnti-Bacterial Agents

Identifiers

PMID40407205
PMCPMC12339195

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.