Evidence map›Paper›PMID 40407177›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Structure, Mechanics, and Mechanobiology of Fibrocartilage Pericellular Matrix Mediated by Type V Collagen.

Chao Wang, Mingyue Fan, Su Chin Heo, Sheila M Adams, Thomas Li, Yuchen Liu, Qing Li, Claudia Loebel, Jason A Burdick, X Lucas Lu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Chao WangSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, 19104, USA.
Mingyue FanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, 19104, USA.
Su Chin HeoMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Sheila M AdamsDepartment of Molecular Pharmacology and Physiology, Morsani School of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Thomas LiSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, 19104, USA.
Yuchen LiuSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, 19104, USA.
Qing LiSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, 19104, USA.
Claudia LoebelDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jason A BurdickBioFrontiers Institute and Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO, 80309, USA.
X Lucas LuDepartment of Mechanical Engineering, University of Delaware, Newark, DE, 19716, USA.
David E BirkDepartment of Molecular Pharmacology and Physiology, Morsani School of Medicine, University of South Florida, Tampa, FL, 33612, USA.
Farid AlisafaeiDepartment of Mechanical and Industrial Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Robert L MauckMcKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Lin HanSchool of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, 19104, USA.ORCID https://orcid.org/0000-0003-4180-1288

Funding

Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)P30AR069619 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI LOUIS J SOSLOWSKY · 2016 to 2026
$9.1M
Dynamic Fibrous Scaffolds for Repairing Dense Connective TissuesR01AR056624 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Jason A Burdick, Robert L Mauck · 2009 to 2026
$7.5M
Mechanical Regulation of Cell Fate and Multi-Scale Function in the Developing MeniscusR01AR075418 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Nathaniel A. Dyment, Lin Han · 2019 to 2026
$4.4M
Biomechanics of Cartilage: Roles of Decorin in ECM Assembly and DegradationR01AR074490 · NIAMS · DREXEL UNIVERSITY · PI Lin Han · 2019 to 2026
$2.3M
Prevention of PTOA via regulation of the cytomechanics of chondrocytesR01AR074472 · NIAMS · UNIVERSITY OF DELAWARE · PI LU, X. LUCAS · 2020 to 2025
$1.5M
National Science Foundation CMMI-1751898National Science Foundation NNCI-1542153NIAMS NIH HHS AR069619NIAMS NIH HHS P30 AR069619NIAMS NIH HHS R01 AR056624NIAMS NIH HHS R01 AR074472NIAMS NIH HHS R01 AR074490NIAMS NIH HHS R01 AR075418NIH HHS P30AR069619NIH HHS R01AR056624NIH HHS R01AR074472NIH HHS R01AR074490NIH HHS R01AR075418
6 · The paper itself

Abstract

The pericellular matrix (PCM) is the immediate microniche surrounding cells in various tissues, regulating matrix turnover, cell-matrix interactions, and disease. This study elucidates the structure-mechanical properties and mechanobiology of the PCM in fibrocartilage, using the murine meniscus as the model. The fibrocartilage PCM is comprised of thin, randomly oriented collagen fibrils that entrap proteoglycans, contrasting with the densely packed, highly aligned collagen fibers in the bulk extracellular matrix (ECM). Compared to the ECM, the PCM exhibits lower modulus and greater isotropy, but has similar relative viscoelastic properties. In Col5a1

Indexed as

Collagen Type VExtracellular MatrixFibrocartilageAnimalsBiomechanical PhenomenaMechanotransduction, CellularMiceCollagen Type Vfibrocartilagemechanotransductionmicromechanicspericellular matrixtype V collagen

Identifiers

PMID40407177
PMCPMC12407281

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.