Evidence map›Paper›PMID 40407103›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Advancing dementia preparedness in Low and Middle Income countries: A randomized trial to improve diagnosis in primary care.

Jorge J Llibre-Guerra, Tania Zayas Llerena, Zaily Martínez Figueroa, Arianna Almirall-Sánchez, Arianne Rodríguez-Velasco, Angel Santos Martínez, Raúl F Gutiérrez-Herrera, Ana M Rodríguez-Salgado, Juan J Llibre-Rodríguez

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jorge J Llibre-GuerraDepartment of Neurology, Washington University in Saint Louis School of Medicine, Saint Louis, Missouri, USA.
Tania Zayas LlerenaDementia Research Unit, Medical University of Havana, Habana, Cuba.
Zaily Martínez FigueroaDementia Research Unit, Medical University of Havana, Habana, Cuba.
Arianna Almirall-SánchezGlobal Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Arianne Rodríguez-VelascoDementia Research Unit, Medical University of Havana, Habana, Cuba.
Angel Santos MartínezDementia Research Unit, Medical University of Havana, Habana, Cuba.
Raúl F Gutiérrez-HerreraDepartment of Family Medicine, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Ana M Rodríguez-SalgadoGlobal Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Juan J Llibre-RodríguezDementia Research Unit, Medical University of Havana, Habana, Cuba.

Funding

Davos Alzheimer's Collaborative
6 · The paper itself

Abstract

introductionDementia disproportionately affects individuals in low- and middle-income countries (LMICs), yet diagnostic capabilities there are often inadequate. This study assesses the impact of a structured training program for primary care physicians (PCPs) in Cuba to improve early dementia detection.

methodsWe conducted a cluster-randomized trial involving 16 primary care clinics, randomizing them into intervention and control groups (CGs). The intervention group (IG) received comprehensive training on dementia diagnosis and management. The effectiveness was measured through changes in diagnosis rates and PCP diagnostic confidence over a 12-month period.

resultsThe IG demonstrated a significant improvement in PCP confidence and dementia diagnosis rates compared to baseline and the CG. Comparisons of clinic-based and community-based dementia prevalence highlighted the effectiveness of the intervention. DISCUSSION: Structured training can significantly enhance the capabilities of PCPs in LMICs for early dementia detection. Ongoing training and integration into health systems are critical for sustaining these improvements. HIGHLIGHTS: This study developed and implemented a tailored training program for PCPs to specifically enhance their skills in dementia diagnosis. We used the 10/66 dementia protocol to benchmark and validate the effectiveness of the training program against community-based prevalence rates. In a cluster-randomized trial, we observed a significant post-training increase in dementia detection in primary care settings. Similar programs may address healthcare disparities by demonstrating the feasibility and impact of educational interventions in resource-constrained settings. We provide evidence-based recommendations for scaling similar training programs across other LMICs to improve dementia care globally.

Indexed as

Clinical CompetenceDementiaDeveloping CountriesPhysicians, Primary CarePrimary Health CareCubaFemaleHumansMaleAlzheimer's diseasedementiadiagnosislow‐ and middle‐income countriesprimary carepublic healthtraining

Identifiers

PMID40407103
PMCPMC12100495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.