Evidence map›Paper›PMID 40407102›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset.

Yuk Yee Leung, Wan-Ping Lee, Amanda B Kuzma, Heather Nicaretta, Otto Valladares, Prabhakaran Gangadharan, Liming Qu, Yi Zhao, Youli Ren, Po-Liang Cheng and 35 more

Abstract read
PubMed Full text at PMC Publisher
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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Article
  2. The Global Parkinson's Disease Genetics (GP2) Genome Browser.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  3. Cross-ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  4. Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Observational
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Gene-Modulated Network Diffusion for Improved Modeling of Amyloid-bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

45 authors.

Yuk Yee LeungDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3047-5440
Wan-Ping LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Amanda B KuzmaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Heather NicarettaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Otto ValladaresDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Prabhakaran GangadharanDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Liming QuDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Yi ZhaoDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Youli RenDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Po-Liang ChengDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pavel P KuksaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hui WangDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Heather WhiteDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Zivadin KatanicDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Lauren BassDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Naveen SaravananDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Emily Greenfest-AllenDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Maureen KirschDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Laura CantwellDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Taha IqbalDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nicholas R WheelerDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
John J FarrellDepartments of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Congcong ZhuDepartments of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Shannon L TurnerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Tamil I GunasekaranColumbia University Irving Medical Center, New York, New York, USA.
Pedro R MenaDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Yumi JinDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Luke CarterDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Alzheimer's Disease Sequencing Project
Xiaoling ZhangDepartments of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Badri N VardarajanColumbia University Irving Medical Center, New York, New York, USA.
Arthur TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA.
Michael CuccaroDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Timothy J HohmanDepartment of Neurology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
William S BushDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Adam C NajDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Eden MartinDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Clifton L DalgardDepartment of Anatomy, Physiology and Genetics, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Brian W KunkleDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Lindsay A FarrerDepartments of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
Richard P MayeuxColumbia University Irving Medical Center, New York, New York, USA.
Jonathan L HainesDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Margaret A Pericak-VanceDepartment of Human Genetics and John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida, USA.
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Li-San WangDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

Large Scale Sequencing and Analysis of GenomesU54HG003067 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY, LANDER, ERIC S · 2004 to 2015
$568.6M
Large Scale Genome SequencingU54HG003079 · NHGRI · WASHINGTON UNIVERSITY · PI DUTCHER, SUSAN K · 2004 to 2016
$445.7M
The Human Genome Sequencing CenterU54HG003273 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2004 to 2015
$341.3M
Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI ARTHUR W TOGA · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI Christine L MacDonald · 2021 to 2026
$80.4M
Vascular Structure and Function in Cognitive AgingP01AG003949 · NIA · YESHIVA UNIVERSITY · PI CHRISTOPHER G ENGELAND · 1985 to 2026
$73.9M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
AbbVieAccelerating Medicines PartnershipAlzheimer Disease Among African Americans Study 2R01AG048927Alzheimer Disease Among African Americans Study 2R01AG09029Alzheimer Disease Among African Americans Study R01AG025259Alzheimer's AssociationAlzheimer's Association "Identification of Rare Variants in Alzheimer Disease"Alzheimer's Disease Centers R01AG044546Alzheimer's Disease Centers R01AG064877Alzheimer's Disease Centers R37AG015473Alzheimer's Disease Centers RF1AG053303Alzheimer's Disease Centers RF1AG058501Alzheimer's Disease Centers U01AG058922Alzheimer's Disease Centers U24AG056270Alzheimer's Disease Neuroimaging Initiative U19AG024904)Alzheimer's Disease Research Centers P30 AG079280Alzheimer's Disease Sequencing Project (ADSP)Alzheimer's Drug Discovery FoundationAlzheimer's Therapeutic Research InstituteAlzheimer's Therapeutic Researc Institute 5R37AG015473Alzheimer's Therapeutic Researc Institute P01AG026276Alzheimer's Therapeutic Researc Institute P01AG03991Alzheimer's Therapeutic Researc Institute P30AG066444Alzheimer's Therapeutic Researc Institute P30AG066462Alzheimer's Therapeutic Researc Institute R01AG044546Alzheimer's Therapeutic Researc Institute R01AG064614Alzheimer's Therapeutic Researc Institute R01AG064877Alzheimer's Therapeutic Researc Institute R56AG051876Alzheimer's Therapeutic Researc Institute RF1AG015473Alzheimer's Therapeutic Researc Institute RF1AG053303Alzheimer's Therapeutic Researc Institute RF1AG054080Alzheimer's Therapeutic Researc Institute RF1AG058501Alzheimer's Therapeutic Researc Institute U01AG052410Alzheimer's Therapeutic Researc Institute U01AG058922American Genome CenterAmish Protective Variant RF1AG058066Anniversary FundAraclon BiotechArizona Alzheimer's Disease Core CenterArizona Department of Health Services AG030653Arizona Department of Health Services AG041718Arizona Department of Health Services AG064877Arizona Department of Health Services K25 AG041906-01Arizona Department of Health Services P30-AG066468Arizona Department of Health Services P30 AG10161Arizona Department of Health Services R01AG046170Arizona Department of Health Services R01AG057907Arizona Department of Health Services R01 AG11101Arizona Department of Health Services R01 AG15819Arizona Department of Health Services R01 AG17917Arizona Department of Health Services R01 AG18023Arizona Department of Health Services R01 AG30146Arizona Department of Health Services RC2AG036528Arizona Department of Health Services RF1AG054014Arizona Department of Health Services RF1AG057440Arizona Department of Health Services U01AG032984Arizona Department of Health Services U24 AG21886Arizona Department of Health Services U54AG052427Arizona Department of Health Services U54NS100693Atherosclerosis Risk in CommunitiesAustrian National BankAustrian Research Promotion agencyAustrian Science FondAustrian Science FundAustrian Stroke Prevention StudyAvid and CogstateBioClinica, Inc.BiogenBRIDGETBroad Institute Genome Center U54HG003067Cache County Study R01AG031272Cache County Study R01AG11380Cache County Study R01AG21136Cache County Study RF1AG054052Cardiovascular Health StudyCase Western Reserve University Brain Bank P50AG008012Case Western Reserve University Rapid Decline NU38CK000480Case Western Reserve University Rapid Decline RF1AG058267Center for Genome TechnologyCereSpir, Inc.Chicago Health and Aging Project R01 AG11101CIHRCogstateCubanAmerican Alzheimer's Disease Initiative 3U01AG052410Culture and ScienceCurePSP U54AG052427CurePSP U54NS100693CurePSP FoundationDarrell K Royal Texas Alzheimer's Initiative P01AG003991Darrell K Royal Texas Alzheimer's Initiative P01AG026276Darrell K Royal Texas Alzheimer's Initiative P01 AG03991Darrell K Royal Texas Alzheimer's Initiative P01AG03991Darrell K Royal Texas Alzheimer's Initiative P30AG066444Darrell K Royal Texas Alzheimer's Initiative P30AG066462Darrell K Royal Texas Alzheimer's Initiative P50 AG05681Darrell K Royal Texas Alzheimer's Initiative R01 AG003949Darrell K Royal Texas Alzheimer's Initiative R01 AG017216Darrell K Royal Texas Alzheimer's Initiative R01 AG025711Darrell K Royal Texas Alzheimer's Initiative R01AG044546Darrell K Royal Texas Alzheimer's Initiative R01AG057777Darrell K Royal Texas Alzheimer's Initiative R01AG058501Darrell K Royal Texas Alzheimer's Initiative R01AG064614Darrell K Royal Texas Alzheimer's Initiative R01AG064877Darrell K Royal Texas Alzheimer's Initiative RF1AG053303Darrell K Royal Texas Alzheimer's Initiative RF1AG054080Darrell K Royal Texas Alzheimer's Initiative RF1AG058501Darrell K Royal Texas Alzheimer's Initiative U01 AG006576Darrell K Royal Texas Alzheimer's Initiative U01AG052410Darrell K Royal Texas Alzheimer's Initiative U01AG058922Department of Internal MedicineDepartments of Neurology and Psychiatry at Washington University School of MedicineEisai Inc.Elan Pharmaceuticals, Inc.Eli Lilly and CompanyErasmus MCErasmus Medical CenterErasmus Rucphen Family StudyErasmus UniversityEstudio Familiar de Influencia Genetica en Alzheimer 5R37AG015473Estudio Familiar de Influencia Genetica en Alzheimer R56AG051876Estudio Familiar de Influencia Genetica en Alzheimer RF1AG015473EU Joint Programme - Neurodegenerative Disease ResearchEuroImmunEuropean CommissionEuropean Community's Seventh Framework HEALTH-F4- 2007-201413European Research CouncilEuropean Special Populations Research NetworkFramingham Heart StudyFujirebioGE HealthcareGenentech, Inc.Genetic and Environmental Risk FactorsGenetic Differences R01 AG007584Genome Center for Alzheimer's Disease U54AG052427German Center for Neurodegenerative DiseasesGHR FoundationGwangju Alzheimer and Related Dementias Study U01AG062602Health Research and DevelopmentHillblom Aging Network 2014-A-004-NETHillblom Aging Network R01AG032289Hillblom Aging Network R01AG048234Hussman Institute for Human GenomicsHussman Institute for Human Genomics Brain BankIbadan Study of Aging 5R01AG009956IXICO Ltd.Janssen Alzheimer Immunotherapy Research & Development, LLCJohnson & Johnson Pharmaceutical Research & Development LLCJohnson & Johnson Pharmaceutical Research & Development LLC.Large Scale Sequencing and Analysis CentersLongevity Genes Project P30AG038072Longevity Genes Project R01AG042188Longevity Genes Project R01AG044829Longevity Genes Project R01AG046949Longevity Genes Project R01AG057909Longevity Genes Project R01AG061155Longitudinal Evaluation of Amyloid Risk and NeurodegenerationLumosityLundbeckMayo Clinic FloridaMayo Parkinson's Disease 5RC2HG005605Mayo Parkinson's Disease NS039764Mayo Parkinson's Disease NS071674Medical Research CouncilMedical Research Council UKMedical University of GrazMemory and Aging Project R01 AG17917Merck & Co., Inc.Meso Scale Diagnostics, LLCMeso Scale Diagnostics, LLC.Mexican Health and Aging Study R01AG018016Ministry for HealthMinistry of EducationMND Victoria P30 AG19610Morris K. Udall Parkinson's Disease Research Center of Excellence #NS072187Multi-Institutional Research in Alzheimer's Genetic Epidemiology 2R01AG048927Multi-Institutional Research in Alzheimer's Genetic Epidemiology 2R01AG09029Multi-Institutional Research in Alzheimer's Genetic Epidemiology R01AG025259Multi-Institutional Research in Alzheimer's Genetic Epidemiology Study R01 AG09029National Institute on Aging Alzheimer's Disease Data Storage SiteNational Institute on Aging Genetics of Alzheimer's Disease Data Storage Site U24AG041689National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site W81XWH-12-2-0012National Institutes of Health-National Institute on AgingNCRR NIH HHS KL2 RR024151Netherlands Consortium for Healthy AgingNetherlands Genomics InitiativeNetherlands OrganizationNetherlands Organization for Scientific ResearchNetherlands Organization for Scientific Research and the Russian Foundation for Basic ResearchNetherlands Organization of Scientific Research NWO InvestmentsNeuroRx ResearchNeurotrack TechnologiesNHGRI NIH HHS RC2 HG005605NHGRI NIH HHS U54 HG003067NHGRI NIH HHS U54 HG003079NHGRI NIH HHS U54 HG003273NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL070825NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL172803NHLBI NIH HHS RC2 HL102419NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U01 HL130114NIA NIH HHS K08 AG034290NIA NIH HHS K23 AG030944NIA NIH HHS K25 AG041906NIA NIH HHS P01 AG003949NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG017216NIA NIH HHS P01 AG017586NIA NIH HHS P01 AG026276NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG008017NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG010129NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG012300NIA NIH HHS P30 AG013846NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG028377NIA NIH HHS P30 AG028383NIA NIH HHS P30 AG038072NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 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HHS R01 AG017917NIA NIH HHS R01 AG018016NIA NIH HHS R01 AG018023NIA NIH HHS R01 AG019085NIA NIH HHS R01 AG019757NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG021136NIA NIH HHS R01 AG021547NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG025259NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG027944NIA NIH HHS R01 AG028786NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG030653NIA NIH HHS R01 AG031272NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG032990NIA NIH HHS R01 AG033040NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG036836NIA NIH HHS R01 AG041718NIA NIH HHS R01 AG041797NIA NIH HHS R01 AG042188NIA NIH HHS R01 AG042210NIA NIH HHS R01 AG043617NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG044829NIA NIH HHS R01 AG046949NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG048927NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG051125NIA NIH HHS R01 AG054047NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG057777NIA NIH HHS R01 AG057907NIA NIH HHS R01 AG057909NIA NIH HHS R01 AG058066NIA NIH HHS R01 AG058501NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG060747NIA NIH HHS R01 AG061155NIA NIH HHS R01 AG063689NIA NIH HHS R01 AG064614NIA NIH HHS R01 AG064877NIA NIH HHS R01 AG074328NIA NIH HHS R01 AG079280NIA NIH HHS R37 AG015473NIA NIH HHS R56 AG051876NIA NIH HHS R56 AG064877NIA NIH HHS RC2 AG036528NIA NIH HHS RC2 AG036547NIA NIH HHS RC4 AG039085NIA NIH HHS RF1 AG015473NIA NIH HHS RF1 AG051504NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG054014NIA NIH HHS RF1 AG054023NIA NIH HHS RF1 AG054047NIA NIH HHS RF1 AG054052NIA NIH HHS RF1 AG054074NIA NIH HHS RF1 AG054080NIA NIH HHS RF1 AG057440NIA NIH HHS RF1 AG057519NIA NIH HHS RF1 AG058066NIA NIH HHS RF1 AG058267NIA NIH HHS RF1 AG058501NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046170NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG049506NIA NIH HHS U01 AG049507NIA NIH HHS U01 AG049508NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG052411NIA NIH HHS U01 AG057659NIA NIH HHS U01 AG058589NIA NIH HHS U01 AG058635NIA NIH HHS U01 AG058654NIA NIH HHS U01 AG058922NIA NIH HHS U01 AG062602NIA NIH HHS U01 AG062943NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG081230NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG066567NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG056270NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NIA NIH HHS U54 AG052427NIA NIH HHS UF1 AG047133NIBIB NIH HHSNIDA NIH HHS HHSN271201300031CNIEHS NIH HHS U01 ES017155NIH HHS U01 AG006781NIH HHS U19 AG066567NIH HHS UF1AG047133NINDS NIH HHS P01 NS026630NINDS NIH HHS P50 NS039764NINDS NIH HHS P50 NS071674NINDS NIH HHS P50 NS072187NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS029993NINDS NIH HHS R01 NS069719NINDS NIH HHS R01 NS080820NINDS NIH HHS U01 NS041588NINDS NIH HHS U24 NS072026NINDS NIH HHS U54 NS100693NINDS NIH HHS UG3 NS104095Northern California Institute for Research and EducationNorthern Manhattan Study R01NS29993Novartis Pharmaceuticals CorporationParkinson's VictoriaPeru Alzheimer's Disease Initiative RF1AG054074Piramal ImagingProspective Dementia Registry-Austriapublic-private-philanthropic partnershipPuerto Rican Alzheimer Disease Initiative RF1AG054074Quality of Life and Management of the Living Resources QLG2-CT-2002- 01254Rainwater Charitable FoundationReasons for Geographic and Racial Differences in StrokeReligious Orders Study P30 AG10161Religious Orders Study P30 AG72975Religious Orders Study R01AG060747Religious Orders Study R01 AG15819Religious Orders Study R01 AG42210Research in African American Alzheimer Disease Initiative U01AG052410Research Institute for Diseases in the ElderlyReta Lila Weston Institute for Neurological StudiesRotterdamRotterdam StudySteiermärkische Krankenanstalten GesellschaftStudy Investigators institutionsTakeda Pharmaceutical CompanyTau Consortium P01AG017586The Longitudinal Aging Study in India R01AG051125The Longitudinal Aging Study in India R01AG064614The Longitudinal Aging Study in India U01AG057659The Longitudinal Aging Study in India U01AG065958The Longitudinal Aging Study in India U24AG041689The Longitudinal Aging Study in India U24 AG21886The Longitudinal Aging Study in India U54AG052427Transition Therapeutics U01AG032984Transition Therapeutics U24AG041689Transition Therapeutics U54AG052427Uniformed Services University of the Health Sciences U01AG057659University of Miami A2011048University of Miami IIRG09133827University of Miami Brain Endowment Bank R01AG028786University of Miami Brain Endowment Bank U01AG052410University of Pennsylvania U24-AG041689University of Toronto (UT)University of Washington Families P50AG005136University of Washington Families R01AG041797University of Washington Families R01NS069719U.S. Department of Health and Human ServicesVictorian Brain BankVictorian Forensic Institute of MedicineWashington University Genome InstituteWelfare and SportsWellcome TrustWisconsin Registry for Alzheimer's Prevention R01AG027161Wisconsin Registry for Alzheimer's Prevention R01AG054047
6 · The paper itself

Abstract

introductionThe Alzheimer's Disease Sequencing Project (ADSP) is a national initiative to understand the genetic architecture of Alzheimer's disease and related dementias (ADRD) by integrating whole genome sequencing (WGS) with other genetic, phenotypic, and harmonized datasets from diverse populations.

methodsThe Genome Center for Alzheimer's Disease (GCAD) uniformly processed WGS from 36,361 ADSP samples, including 35,014 genetically unique participants of which 45% are from non-European ancestry, across 17 cohorts in 14 countries in this fourth release (R4).

resultsThis sequencing effort identified 387 million bi-allelic variants, 42 million short insertions/deletions, and 6.8 million structural variants. Annotations and quality control data are available for all variants and samples. Additionally, detailed phenotypes from 15,927 participants across 10 domains are also provided. A linkage disequilibrium panel was created using unrelated AD cases and controls. DISCUSSION: Researchers can access and analyze the genetic data via the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) Data Sharing Service, the VariXam, or NIAGADS GenomicsDB. HIGHLIGHTS: We detailed the genetic architecture and quality of the Alzheimer's Disease Sequencing Project release 4 whole genome sequences. We identified 435 million single nucleotide polymorphisms, insertions and deletions, and structural variants from diverse genomes. We harmonized extensive phenotypes, linkage disequilibrium reference panel on subset of samples. Data is publicly available at NIAGADS Data Storage Site, variants and annotations are browsable on two different websites.

Indexed as

Alzheimer DiseaseDatabases, GeneticWhole Genome SequencingHumansLinkage DisequilibriumPhenotypeAlzheimer's diseasediversitygenetic architecturegenetics data sharinggenetics knowledgebaselinkage disequilibrium reference panelwhole genome sequencing

Identifiers

PMID40407102
PMCPMC12100500

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