ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Regional variability of the impact of cardiometabolic diseases on incident dementia in United States Medicare beneficiaries.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Trends and Disparities in Dementia Among Older Adults With Coronary Artery Disease, 1999-2023: Insights From the CDC WONDER Database.Brain and behavior · 2025Article
- Liver Fibrosis and Risk of Incident Dementia in the General Population: Systematic Review With Meta-Analysis.Health science reports · 2025Review
- Enhancing uptake of antidiabetic drugs to reduce cardiometabolic risk and dementia burden.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Karway et al. respond to "Enhancing uptake of antidiabetic drugs to reduce cardiometabolic risk and dementia burden".Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The cardiometabolic "bottleneck" on cognitive function in aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Regional variability of the impact of cardiometabolic diseases on incident dementia in United States Medicare beneficiaries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionUnderstanding the impact of cardiometabolic diseases (CMDs) on dementia risk can inform primary preventative measures.
methodsWe leveraged a nationwide, population-based Medicare dataset of 20,789,037 beneficiaries (756,321 with incident dementia and 20,032,716 controls) from 2017 to compute the individual and combined population attributable fractions (PAFs) of dementia attributed to eight CMDs, adjusted for age, sex, and race. We mapped PAFs at the county level to investigate the geospatial patterns of CMD burden on dementia across the United States.
resultsThe nationwide combined weighted PAF for the eight CMDs was 37% overall, with hypertension (9.6%), ischemic heart disease (6.7%), and chronic heart failure (5.7%) associated with the greatest attributable fractions of dementia cases. The greatest fraction of county-level dementia cases attributed to CMDs were in the Southeastern United States. DISCUSSION: A substantial proportion of incident dementia cases in the United States can be attributed to CMDs, especially in the Southeastern United States. HIGHLIGHTS: Investigated the combined effect of cardiometabolic diseases (CMDs) on dementia. Used novel geospatial techniques to map the burden of dementia attributed to CMDs. If eight CMDs are mitigated, 37% of incident dementia cases could be eliminated. Identified regions of the United States with high CMD burden on dementia.
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