Evidence map›Paper›PMID 40407028›Full record

ArticleChembiochem : a European journal of chemical biology2025

A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for Cell-Membrane Permeable Inhibitors for the Interaction Between Estrogen Receptor α and Coactivator SRC1.

Daisuke Fujiwara, Shunsuke Inaura, Yuna Tanaka, Sayoko Ito-Harashima, Asako Yamaguchi-Nomoto, Masanobu Kawanishi, Takashi Yagi, Ikuhiko Nakase, Ikuo Fujii

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daisuke FujiwaraGraduate School of Science, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.ORCID https://orcid.org/0000-0002-6230-5534
Shunsuke InauraGraduate School of Science, Osaka Prefecture University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.
Yuna TanakaGraduate School of Science, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.
Sayoko Ito-HarashimaGraduate School of Agriculture, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.ORCID https://orcid.org/0009-0002-8884-7937
Asako Yamaguchi-NomotoGraduate School of Science, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.ORCID https://orcid.org/0000-0002-6242-4787
Masanobu KawanishiGraduate School of Science, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.
Takashi YagiGraduate School of Science, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.
Ikuhiko NakaseGraduate School of Science, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.ORCID https://orcid.org/0000-0002-2476-2435
Ikuo FujiiGraduate School of Science, Osaka Metropolitan University, Gakuen-cho 1-1, Sakai, Osaka, 599-8531, Japan.ORCID https://orcid.org/0000-0003-2571-546X

Funding

Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from Japan Agency for Medical Research and Development (AMED) JP24am121036
6 · The paper itself

Abstract

The molecular design of inhibitors against intracellular protein-protein interactions (PPIs) is of interest for drug discovery and chemical biology. Herein, a novel cyclized helix-loop-helix (cHLH) peptide that inhibited the intracellular PPI between estrogen receptor alpha (ERα) and coactivator SRC1 are designed. The peptide, cHLH-ERα, bound to ERα and inhibited the interaction between ERα and the coactivator SRC1. Cellular imaging and yeast reporter assays showed that cHLH-ERα penetrated the cell membrane and exhibited antagonistic activity against ERα-SRC1 to inhibit the growth of a breast cancer cell.

Indexed as

Estrogen Receptor alphaNuclear Receptor Coactivator 1Peptides, CyclicCell Membrane PermeabilityCell ProliferationHelix-Loop-Helix MotifsHumansProtein BindingESR1 protein, humanEstrogen Receptor alphaNCOA1 protein, humanNuclear Receptor Coactivator 1Peptides, Cycliccell membrane permeabilityinhibitornuclear receptorspeptidesprotein–protein interactions

Identifiers

PMID40407028
PMCPMC12247020

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.