Evidence map›Paper›PMID 40406993›Full record

ArticleJournal of medicinal chemistry2025

A Predictive Model for Thiol Reactivity of

Mariah C Meehan, Grace E Scofield, Corrinne E Stahl, Jacob A Wolfe, W Seth Horne, Peng Liu, Kay M Brummond

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mariah C MeehanDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.
Grace E ScofieldDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0009-0002-9651-2088
Corrinne E StahlDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0009-0006-7363-9325
Jacob A WolfeDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0001-9335-6070
W Seth HorneDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0003-2927-1739
Peng LiuDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0002-8188-632X
Kay M BrummondDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0003-3595-6806

Funding

Computational Models for Reactivity and Selectivity in Transition Metal-Catalyzed Olefin FunctionalizationR35GM128779 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peng Liu · 2018 to 2026
$2.9M
Exploring the Impact of Altered Backbone Composition on Protein Folding and FunctionR35GM149220 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILLIAM SETH HORNE · 2023 to 2026
$1.4M
NIGMS NIH HHS R35 GM128779NIGMS NIH HHS R35 GM149220
6 · The paper itself

Abstract

Herein, we present a systematic study on the effects of electronically diverse heteroarenes on the rate of glutathione (GSH) addition to novel

Indexed as

Cysteine Proteinase InhibitorsLactamsSulfhydryl CompoundsGlutathioneHeterocyclic CompoundsKineticsMolecular StructureStructure-Activity RelationshipCysteine Proteinase InhibitorsGlutathioneHeterocyclic CompoundsLactamsSulfhydryl Compounds

Identifiers

PMID40406993
PMCPMC12169685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.