ArticleThe Journal of international medical research2025
The therapeutic potential of irisin in alleviating acute lung injury via inflammation and ferroptosis modulation.
Article in The Journal of international medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Natural products in treating sepsis-associated lung and liver injuries by mediating ferroptosis, current progress, and future perspective.Frontiers in pharmacology · 2026Review
- Ferroptosis: molecular mechanisms, pathophysiology, and role in pediatric pulmonary diseases.Cell biology and toxicology · 2025Review
- Ferroptosis in sepsis induced acute lung injury/acute respiratory distress syndrome (ALI/ARDS): a potential therapeutic strategy.Frontiers in immunology · 2025Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
ObjectiveAcute lung injury is a fatal complication triggered by sepsis, characterized by widespread inflammation and weakening of the alveolar epithelium. Irisin has been reported to exert anti-inflammatory effects, which are produced by the cleavage of fibronectin type III domain-containing protein 5 in skeletal muscle. Here, we investigated the potential of irisin in preventing acute lung injury by protecting the alveolar epithelium.MethodsThe sepsis-related acute lung injury model was established by a cecal ligation and puncture model in C57/BL6N mice. Lung histology was assessed using hematoxylin and eosin and Masson staining. Ferroptosis-related proteins and genes were quantified via western blot and quantitative polymerase chain reaction, respectively, whereas cytokine levels were measured using enzyme-linked immunosorbent assay.ResultsHistological analysis revealed lung injury in the cecal ligation and puncture group, alongside elevated levels of cytokines such as IL-1β, IL-18, and TNF-α compared with controls. Treatment with irisin mitigated sepsis-induced lung damage and reduced oxidative stress, as indicated by reactive oxygen species and Fe
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