Evidence map›Paper›PMID 40406819›Full record

ArticleThe Medical journal of Australia2025

The first live term birth following uterus transplantation in Australia.

Rebecca Deans, Brigitte Gerstl, Antonia W Shand, Sarah Lyons, Aaron Budden, Helen L Barrett, Grant Luxton, Mangalee Fernando, Kenneth Yong, Karen Keung and 12 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Medical journal of Australia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Risks of uterus transplantation: a scoping review.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2026
    Article
  2. Past, Present, and Future: A Review of Uterus Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Rebecca DeansRoyal Hospital for Women, Sydney, NSW.
Brigitte GerstlThe University of New South Wales, Sydney, NSW.ORCID 0000-0003-1848-056X
Antonia W ShandRoyal Hospital for Women, Sydney, NSW.ORCID 0000-0002-4200-9295
Sarah LyonsRoyal Hospital for Women, Sydney, NSW.
Aaron BuddenWomen's Reproductive Care, Coffs Harbour, NSW.
Helen L BarrettRoyal Hospital for Women, Sydney, NSW.
Grant LuxtonPrince of Wales Hospital, Sydney, NSW.
Mangalee FernandoPrince of Wales Hospital, Sydney, NSW.
Kenneth YongPrince of Wales Hospital, Sydney, NSW.
Karen KeungPrince of Wales Hospital, Sydney, NSW.
Kaushalya ArulpragasamRoyal Hospital for Women, Sydney, NSW.
Henry PleassWestmead Hospital, Sydney, NSW.
King Man WanRoyal Hospital for Women, Sydney, NSW.
Eva KehagRoyal Hospital for Women, Sydney, NSW.
Jana-Emily PittmanRoyal Hospital for Women, Sydney, NSW.ORCID 0000-0001-6111-6996
Mianna LotzMacquarie University, Sydney, NSW.
Maria FennRoyal Hospital for Women, Sydney, NSW.
Erin Nesbitt-HawesRoyal Hospital for Women, Sydney, NSW.
Lily ByunRoyal Hospital for Women, Sydney, NSW.
Katrina TangNSW Health Pathology, Sydney, NSW.
Mats BrannstromSahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Jason AbbottRoyal Hospital for Women, Sydney, NSW.

Funding

Royal Hospital for Women Foundation
6 · The paper itself

Abstract

objectiveTo report the first live birth following uterus transplantation in Australia. STUDY

designCase report. SETTING, PARTICIPANT: The first participant in the uterus transplantation research study program at the Royal Hospital for Women, the Prince of Wales Hospital, and Westmead Hospital in Sydney.

main outcome measuresClinical course after uterus transplantation; course of the subsequent pregnancy until delivery.

resultsThe immunosuppression regimen following uterus transplantation on 10 January 2023 was similar to that used for low immunologic risk kidney transplantation. It included induction therapy (basiliximab on days 0 and 4, methylprednisolone on days 0 and 1), followed by maintenance therapy with oral tacrolimus, prednisolone, and mycophenolate mofetil (MMF). The prednisolone dose was steadily tapered over twelve weeks to a low maintenance dose (from 25 mg to 5 mg daily); MMF was replaced with azathioprine during week 9, and tacrolimus was continued throughout the pregnancy. There was no evidence of rejection. A frozen grade 1 blastocyst was transferred during a natural ovulatory cycle 101 days (fifteen weeks) after transplantation; clinical pregnancy was successfully initiated. The woman developed gestational diabetes at 20 weeks and was treated with insulin. A healthy boy was born by planned caesarean delivery at 37 weeks; he weighed 2990 g, with Apgar scores of 7 at one minute and 9 at five minutes. Intrapartum haemorrhage (estimated 2500 mL) led to iron infusion after delivery. The woman and her infant were discharged from the hospital five days after the birth. The infant was breastfed, but the woman experienced recurrent episodes of mastitis that were managed with oral antibiotics, and intravenous antibiotics during two hospital admissions. Eight weeks after birth she commenced weaning the infant. Neither the woman nor her infant experienced serious complications.

conclusionThe first live birth following uterus transplantation in Australia indicates that the procedure could be adopted here as an assisted reproductive technology for women with uterine factor infertility.

trial registrationAustralian and New Zealand Clinical Trials registry, ACTRN12622000917730.

Indexed as

Live BirthUterusAustraliaFemaleHumansImmunosuppressive AgentsInfant, NewbornMalePregnancyImmunosuppressive AgentsBirth weightImmunosuppressionInfertilityPregnancyTransplantation

Identifiers

PMID40406819
PMCPMC12536079

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.