ArticleJournal of inflammation research2025
Identification of Fatty Acid Metabolism Disorder-Related Gene Signature in Septic Cardiomyopathy.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- KIF13B Attenuates Sepsis-Induced Myocardial Dysfunction through the Stabilization of PLIN5.Research (Washington, D.C.) · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Septic cardiomyopathy (SCM) is a prevalent complication of sepsis and a primary contributor to mortality in patients with sepsis. Although fatty acid metabolism (FAM) is known to regulate cardiac function, its specific role in the pathogenesis of SCM remains unclear. Methods: The SCM datasets were obtained from the NCBI GEO database. Differentially expressed genes (DEGs) were subjected to GO and KEGG pathway analyses. The fatty acid metabolism-related genes were obtained from the MSigDB database. CytoHubba and machine learning algorithms identified hub FAM-DEGs. Associated transcriptional factors and miRNAs of hub FAM-DEGs were predicted using Cytoscape software and miRWalk 3.0 database. The immune infiltration pattern in SCM was analyzed using the ImmuCellAI tool. The relationship between hub FAM-DEGs and immune infiltration abundance was investigated using Spearman method. Hub FAM-DEGs expression levels were validated in clinical samples and mouse models. Results: Five hub FAM-DEGs associated with SCM were identified, including Conclusion: This study revealed fatty acid metabolism played a crucial role in SCM and identified DHCR24 may act as a potential diagnostic biomarker and therapeutic target in SCM.
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