Evidence map›Paper›PMID 40406677›Full record

ArticleJournal of Alzheimer's disease reports

The diagnostic accuracy of CTseg segmentation software for dementia in a New Zealand memory service.

Mukish Yelanchezian, Cristian Gonzalez-Prieto, Bede Oulaghan, Susan Yates, Catherine Morgan, Gill Dobbie, Daniel Davis, Sarah Cullum

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mukish YelanchezianSchool of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0003-2922-5409
Cristian Gonzalez-PrietoSchool of Computer Science, Faculty of Science, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-1567-9488
Bede OulaghanMiddlemore Hospital, Te Whatu Ora Counties Manukau, South Auckland, New Zealand.
Susan YatesSchool of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0001-7551-5517
Catherine MorganCentre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-5837-8861
Gill DobbieSchool of Computer Science, Faculty of Science, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0001-7245-0367
Daniel DavisMRC Unit for Lifelong Health and Ageing, University College London, London, UK.ORCID https://orcid.org/0000-0002-1560-1955
Sarah CullumSchool of Medicine, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.ORCID https://orcid.org/0000-0003-0785-9101

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study examines the accuracy of CTseg segmentation software to diagnose Alzheimer's disease dementia and other dementias using routine CT scans from a New Zealand memory service. Analyzing 168 scans (89 with dementia and 79 without dementia) the software segmented the brain to produce total brain volume and hippocampal volume. CTseg-derived total brain volume (sensitivity 72%, specificity 58%) and hippocampal volume (sensitivity 71%, specificity 62%) were reasonably effective at differentiating dementia from non-dementia at time of diagnosis. Our findings suggest that CTseg automated volumetric analysis has some potential to aid dementia diagnosis in real-world clinical settings.

Indexed as

Alzheimer's diseasecomputer-assisteddementiaearly diagnosisimage processingneuroimagingsensitivity and specificitytomographyx-ray computed

Identifiers

PMID40406677
PMCPMC12095946

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.