Evidence map›Paper›PMID 40406632›Full record

ArticleEnvironmental epigenetics2025

Extended abstinence from morphine alters sperm smRNA expression and prevents transmission of intergenerational phenotypes.

Dana Zeid, Andre B Toussaint, Carmen Dressler, Angela Harbeck, Reza Karbalaei, Yandrés Cintrón, Andrew Pan, Mathieu Wimmer

Abstract read
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In one paragraph

Article in Environmental epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dana ZeidDepartment of Psychology & Neuroscience, College of Liberal Arts, Temple University, Philadelphia, PA 19122, United States.ORCID https://orcid.org/0000-0001-7666-1428
Andre B ToussaintZuckerman Mind, Brain, and Behavior Institute, Columbia University, New York, NY 10027, United States.
Carmen DresslerDepartment of Psychology & Neuroscience, College of Liberal Arts, Temple University, Philadelphia, PA 19122, United States.
Angela HarbeckDepartment of Psychology & Neuroscience, College of Liberal Arts, Temple University, Philadelphia, PA 19122, United States.
Reza KarbalaeiDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Baltimore 21205, United States.
Yandrés CintrónDepartment of Psychology & Neuroscience, College of Liberal Arts, Temple University, Philadelphia, PA 19122, United States.
Andrew PanDepartment of Psychology & Neuroscience, College of Liberal Arts, Temple University, Philadelphia, PA 19122, United States.
Mathieu WimmerDepartment of Psychology & Neuroscience, College of Liberal Arts, Temple University, Philadelphia, PA 19122, United States.

Funding

Unraveling Epigenetic Mechanisms Of Opioid Addiction Susceptibility Using Multigenerational Animal ModelsDP1DA046537 · NIDA · TEMPLE UNIV OF THE COMMONWEALTH · PI WIMMER, MATHIEU · 2018 to 2022
$2.5M
Mechanisms Underlying Learning Deficits Caused by Paternal Cocaine TakingK01DA039308 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI WIMMER, MATHIEU · 2016 to 2020
$903k
NIDA NIH HHS DP1 DA046537NIDA NIH HHS K01 DA039308
6 · The paper itself

Abstract

Paternal exposure to drugs of abuse can impact addiction-related behaviours in progeny via germline epigenome remodelling. Previously, we found that offspring of morphine-exposed male rats showed increased morphine-taking, diminished adolescent social play, and increased sensitivity to morphine-derived analgesia. Here, we first tested the impact of a 90-day paternal abstinence period following morphine self-administration on the transmission of the aforementioned phenotypes. The previously observed changes in morphine-related behaviours were no longer present in offspring of morphine-abstinent sires. We next compared small RNA (smRNA) content in sperm collected from four sire intravenous self-administration groups: morphine, saline, abstinent morphine, and abstinent saline. Two smRNAs (rno-miR-150-5p and an snoRNA annotated to

Indexed as

Epigenetic inheritanceintergenerational inheritancemiRNAopioidsperm RNA

Identifiers

PMID40406632
PMCPMC12097204

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.