Evidence map›Paper›PMID 40406500›Full record

ArticleiScience2025

Ribosomal protein deficiencies linked to Diamond-Blackfan anemia induce distinctive alterations of ATF4 expression.

L Francisco Lorenzo-Martín, Javier Robles-Valero, Rosa Ramírez-Cota, Sonia G Gaspar, Pedro Fuentes, Antonio Gentilella, Xosé R Bustelo, Mercedes Dosil

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PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. RiboScreenBiomedicines · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

L Francisco Lorenzo-MartínCentro de Investigación del Cáncer, CSIC-University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain.
Javier Robles-ValeroCentro de Investigación del Cáncer, CSIC-University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain.
Rosa Ramírez-CotaCentro de Investigación del Cáncer, CSIC-University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain.
Sonia G GasparCentro de Investigación del Cáncer, CSIC-University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain.
Pedro FuentesLaboratory of Cancer Metabolism, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Antonio GentilellaLaboratory of Cancer Metabolism, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
Xosé R BusteloCentro de Investigación del Cáncer, CSIC-University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain.
Mercedes DosilCentro de Investigación del Cáncer, CSIC-University of Salamanca, Campus Unamuno, 37007 Salamanca, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ribosomal protein haploinsufficiency causes Diamond-Blackfan anemia (DBA) and other ribosomopathies. DBA has been linked to p53 activation and reduced GATA1 expression, but these mechanisms do not fully explain the disease. This study unveils that deficiencies in small (RPS) or large (RPL) ribosomal subunit proteins cause a p53-independent loss of ATF4, a master regulator of stress responses and erythropoiesis, by reducing the pool of actively translating

Indexed as

Biochemistrymolecular biologyomics

Identifiers

PMID40406500
PMCPMC12096137

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.