Evidence map›Paper›PMID 40406479›Full record

SynthesisRevista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia2025

Efficacy of tranexamic acid application in gynecology and obstetrics procedures: a umbrella review of systematic reviews of randomized trials.

Nicole Cristina Lottermann, Nathalia Luiza Andreazza, Matheus de Araújo Moura Cavalcante, Laura Andrade Fernandez, Carla Vitola Gonçalvez, Linjie Zhang

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Uses of tranexamic acid and the risk of thrombosis in women: Number 11 - 2025.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nicole Cristina LottermannUniversidade Federal do Rio Grande Rio GrandeRS Brazil Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.ORCID https://orcid.org/0000-0003-3367-184X
Nathalia Luiza AndreazzaUniversidade Federal do Rio Grande Rio GrandeRS Brazil Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.ORCID https://orcid.org/0000-0001-6994-9749
Matheus de Araújo Moura CavalcanteUniversidade Federal do Rio Grande Rio GrandeRS Brazil Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.ORCID https://orcid.org/0000-0002-1889-2241
Laura Andrade FernandezUniversidade Federal do Rio Grande Rio GrandeRS Brazil Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.ORCID https://orcid.org/0009-0005-6198-8379
Carla Vitola GonçalvezUniversidade Federal do Rio Grande Rio GrandeRS Brazil Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.ORCID https://orcid.org/0000-0001-6580-6417
Linjie ZhangUniversidade Federal do Rio Grande Rio GrandeRS Brazil Universidade Federal do Rio Grande, Rio Grande, RS, Brazil.ORCID https://orcid.org/0000-0003-0300-6953

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This umbrella review aimed to synthesize evidence from systematic reviews of clinical trials on the efficacy of tranexamic acid in gynecology and obstetrics procedures. Methods: We searched Medline, Embase, SciELO and Cochrane Database of Systematic Reviews on March 11, 2024, using the term "tranexamic acid". Four reviewers independently select studies and extract data. We assessed the quality of systematic review and the quality of evidence, using AMSTAR 2 and GRADE tools, respectively. Results: Of 651 systematic reviews identified, 16 reviews with 96663 patients were included. The surgical procedures were cesarean section, myomectomy, hysterectomy, and cervical intraepithelial neoplasia surgery. All reviews showed a statistically significant and clinically relevant reduction in intraoperative and post-procedure blood loss, associated with intravenous or topical use of tranexamic acid. Tranexamic acid resulted in a significant reduction in the need for blood transfusions and a less pronounced drop in postoperative hematocrit and hemoglobin levels in cesarean section. Several reviews addressed the same question, but the number of included trials varied substantially, which might indicate flaws in search and selection of studies of these reviews. The quality of systematic reviews was low or critically low, and the quality of evidence was moderate. Conclusions: This umbrella review shows that tranexamic acid can reduce blood loss and hemorrhage in gynecology and obstetrics procedures. High quality systematic reviews are still needed.

Indexed as

Antifibrinolytic AgentsBlood Loss, SurgicalObstetric Surgical ProceduresTranexamic AcidFemaleHumansPregnancyRandomized Controlled Trials as TopicSystematic Reviews as TopicTreatment OutcomeAntifibrinolytic AgentsTranexamic AcidBlood transfusionCesarean sectionEfficacyGynecologic surgical proceduresHematocritHemorrhageHysterectomyObstetric surgical proceduresTranexamic acidUterine cervical dysplasiaUterine myomectomy

Identifiers

PMID40406479
PMCPMC12097445

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.