Evidence map›Paper›PMID 40406463›Full record

ArticlebioRxiv : the preprint server for biology2025

TlyA is a 23S and 16S 2'-O-methylcytidine methyltransferase important for ribosome assembly in

Jennie L Hibma, Lia M Munson, Joshua D Jones, Taylor M Nye, Kristin S Koutmou, Lyle A Simmons

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jennie L HibmaDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Lia M MunsonDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Joshua D JonesDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109.
Taylor M NyeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.
Kristin S KoutmouDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109.
Lyle A SimmonsDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109.

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Mechanisms of translational controlR35GM128836 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristin S Koutmou · 2018 to 2026
$3.2M
Novel mechanisms of DNA repair and cell cycle regulation in bacteriaR35GM131772 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lyle Simmons · 2019 to 2026
$2.8M
MFB: Integrating LC-MS/MS and Nanopore Sequencing Platforms to Enable the Direct and Quantatative Detection of RNA ModificationsR01HG013876 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristin S Koutmou · 2024 to 2026
$1.2M
NHGRI NIH HHS R01 HG013876NIGMS NIH HHS R35 GM128836NIGMS NIH HHS R35 GM131772NIGMS NIH HHS T32 GM007544
6 · The paper itself

Abstract

Ribosomal RNA (rRNA) is methylated in organisms ranging from bacteria to metazoans. Despite the pervasiveness of rRNA methylation in biology, the function of rRNA methylation on ribosome function is poorly understood. In this work, we identify a biological function for the rRNA 2'-O-methylcytidine methyltransferase TlyA, conserved between

Indexed as

antibioticsBacillus subtilisribosomeRNA methylationtranslation

Identifiers

PMID40406463
PMCPMC12097680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.