ArticleOpen forum infectious diseases2025
Trajectories of Health-Related Quality of Life 2 Years After Mild/Moderate Severe Acute Respiratory Syndrome Coronavirus 2 Infection in the Pre-Omicron Era.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Lived Experiences of Long COVID in Iranian Immigrants in Canada: Implications for Post-Infection Care and Global Health Equity.Iranian journal of medical sciences · 2026Article
- Population-based comparison of post-acute sequelae of COVID-19 and health-related quality of life across pandemic periods: Omicron era versus early pandemic.Scientific reports · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Individuals with postacute sequelae of coronavirus disease 2019 (COVID-19), or long COVID, experience substantial burden of illness many months after initial infection. Few studies have comprehensively and longitudinally assessed health outcomes for people with long COVID following mild/moderate infection. We applied the Wilson-Cleary model of health-related quality of life (HRQOL) to describe the impact of long COVID on multiple health dimensions up to 24 months following mild/moderate COVID-19. Methods: Participants within the ADAPT post-COVID study (N = 172, 86% mild/moderate infection) completed structured patient-reported outcome measures at 4, 8, 12, 18, and 24 months postinfection. Following the Wilson-Cleary model, questionnaires assessed symptoms (anxiety/depression, chronic fatigue, breathlessness), return to pre-COVID-19 functioning, perceived health status (EuroQol Visual Analogue Scale), and wellbeing (EuroQol EQ-5D-5L, Personal Wellbeing Index). Temporal trends were assessed using general estimating equations and ordinal logistic regression, including time × long COVID interactions. Results: Thirty-seven percent of participants were diagnosed with long COVID (≥1 new/persisting symptoms of chest pain, breathlessness, or fatigue/malaise at least 12 weeks after infection). Long COVID was associated with poorer health outcomes across all domains at first assessment. Over 2 years, participants with long COVID reported improvement in return to pre-COVID-19 work and Somatic and Psychological Health Report chronic fatigue but sustained impairment was observed in all other health domains, compared to participants recovered from COVID-19. Conclusions: Substantial long-term impairment in various health domains were observed for individuals with long COVID following mild/moderate initial infection, with little improvement over time in most. Multimodal interventions must address impairment in multiple domains of HRQOL in individuals with long COVID.
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