ArticleWorld journal of emergency medicine2025
Uncovering host response in adults with severe community-acquired pneumonia: a proteomics and metabolomics perspective study.
Article in World journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Artificial intelligence in the diagnosis and prognosis of pediatric bacterial pneumonia: current advances and challenges.Current opinion in pediatrics · 2026Review
- Exercise interventions remodel the aging microenvironment to improve prognosis in older patients with cancer.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCommunity-acquired pneumonia (CAP) represents a significant public health concern due to its widespread prevalence and substantial healthcare costs. This study was to utilize an integrated proteomic and metabolomic approach to explore the mechanisms involved in severe CAP.
methodsWe integrated proteomics and metabolomics data to identify potential biomarkers for early diagnosis of severe CAP. Plasma samples were collected from 46 CAP patients (including 27 with severe CAP and 19 with non-severe CAP) and 19 healthy controls upon admission. A comprehensive analysis of the combined proteomics and metabolomics data was then performed to elucidate the key pathological features associated with CAP severity.
resultsThe proteomic and metabolic signature was markedly different between CAPs and healthy controls. Pathway analysis of changes revealed complement and coagulation cascades, ribosome, tumor necrosis factor (TNF) signaling pathway and lipid metabolic process as contributors to CAP. Furthermore, alterations in lipid metabolism, including sphingolipids and phosphatidylcholines (PCs), and dysregulation of cadherin binding were observed, potentially contributing to the development of severe CAP. Specifically, within the severe CAP group, sphingosine-1-phosphate (S1P) and apolipoproteins (APOC1 and APOA2) levels were downregulated, while S100P level was significantly upregulated.
conclusionThe combined proteomic and metabolomic analysis may elucidate the complexity of CAP severity and inform the development of improved diagnostic tools.
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