ArticleFrontiers in oncology2025
Case Report: Alpha-fetoprotein-producing urothelial carcinoma of the bladder.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Elevated serum levels of alpha-fetoprotein (AFP) are commonly associated with hepatocellular carcinoma or germ cell tumors. AFP-producing urothelial carcinoma of the bladder is very rare. We report a case of bladder urothelial carcinoma with significantly elevated AFP levels. A 60-year-old man was admitted for gross hematuria. Computed tomography urography revealed multiple large tumors of the bladder. The serum level of AFP was up to 2,329 ng/ml. No hepatic tumors or testicular tumors were detected. Although the hepatitis B surface antigen test was positive, the liver function test was normal. The patient underwent robotic-assisted laparoscopic radical cystectomy with ileal conduit urinary diversion. Postoperative pathology revealed high-grade muscle invasive bladder urothelial carcinoma and immunohistochemical staining of the tumor cells showed strong AFP positivity. After surgery, the patient's serum AFP levels dropped sharply and decreased to normal 4 weeks after the operation. In conclusion, AFP-producing bladder urothelial carcinoma is rare, and the mechanism and pathophysiology remain unclear and require further investigation.
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