Evidence map›Paper›PMID 40406258›Full record

ArticleFrontiers in oncology2025

Revisiting the molecular landscape of Rosai-Dorfman disease: insights from whole exome sequencing of Saudi patients.

Sarah Binhassan, Manar Samman, Yazeed Al-Sheikh, Wafaa Alshakweer, Tahani Alhalouli, Najd Alshamlan, Manal Abudawood

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah BinhassanDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Manar SammanMolecular Pathology (Genetics) Section, Pathology and Clinical Laboratory Medicine Administration, King Fahad Medical City, Riyadh, Saudi Arabia.
Yazeed Al-SheikhDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Wafaa AlshakweerDepartment of Pathology and Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.
Tahani AlhalouliDepartment of Pathology and Laboratory Medicine, King Fahad Medical City, Riyadh, Saudi Arabia.
Najd AlshamlanDepartment of Pathology and Laboratory Medicine, King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi Arabia.
Manal AbudawoodDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rosai-Dorfman disease (RDD) has traditionally been viewed as a reactive histiocytic disorder, defined by its unique clinical features and immunophenotype. However, recent genetic studies suggest a more complex molecular landscape, challenging the notion of RDD as solely reactive and hinting at a possible neoplastic component. Mutations in MAPK/ERK pathway genes, such as

Indexed as

BRCA1 mutationgenetic landscapemolecular markersRosai-Dorfman diseasewhole exome sequencing

Identifiers

PMID40406258
PMCPMC12094912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.