ArticleJournal of orthopaedics and sports medicine2025
Surgical interventions in Severe Osteoarthritis: Pros and Cons.
Article in Journal of orthopaedics and sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Comparative efficacy of transdermal buprenorphine versus diclofenac in the management of knee osteoarthritis: a randomized controlled trial with network pharmacology insights.Inflammopharmacology · 2026Trial
- Gait Biomechanics, Symmetry Restoration, and Functional Recovery Following Total Knee Arthroplasty: A Prospective Longitudinal Cohort Study.Life (Basel, Switzerland) · 2026Article
- Periarticular Embolization as an Alternative Treatment for Surgery-Ineligible Patients with Hip Osteoarthritis: A Prospective Comparative Study.Journal of clinical medicine · 2026Article
- Clinical outcomes of solid organ transplant patients after total joint arthroplasty: a propensity-matched analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Article
- Comparative analysis of postoperative outcomes in men and women following total hip replacement surgery.Journal of orthopaedic surgery and research · 2026Article
- Article
- Comparing Regenerative Biologics and Standard Pharmacotherapy for Chronic Rotator Cuff Tendinopathy: A Study of PRP, Cell-Based, and Peptide Interventions.Journal of orthopaedics and sports medicine · 2026Article
- Integrating Mechanical Diagnosis and Therapy Within Multidisciplinary Biopsychosocial Care for Chronic Musculoskeletal Pain.Journal of orthopaedics and sports medicine · 2026Article
- A New Way to Engineer Cell Sheets for Articular Cartilage Regeneration.Journal of functional biomaterials · 2025Article
- The Role of Extracellular Vesicles in Musculoskeletal Diseases.Journal of extracellular vesicles · 2025Review
- Management of Venous Thromboembolism After Hip and Knee Arthroplasty.Journal of orthopaedics and sports medicine · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Severe osteoarthritis (OA) is a debilitating condition that often necessitates surgical intervention when conservative treatments fail. We carefully reviewed the literature on the pros and cons of surgical options for severe OA, focusing on total joint arthroplasty (TJA) and other surgical techniques. Total joint arthroplasty, including total knee arthroplasty (TKA) and total hip arthroplasty (THA), is the most established surgical option for severe OA, providing significant pain relief, functional restoration, and improved quality of life. The American College of Rheumatology and the American Association of Hip and Knee Surgeons recommend proceeding to TJA without delay in patients with symptomatic moderate-to-severe OA unresponsive to nonoperative therapy. Osteotomies and cartilage repair procedures are less commonly performed and have limited evidence supporting their long-term efficacy in reducing OA progression. Arthroscopic interventions, such as lavage and debridement, do not alter disease progression and are not recommended for routine treatment of OA. While TJA is highly effective, it is associated with risks such as postoperative complications, revisions, and reoperations. The cost-effectiveness of TJA is well-documented, making it a favorable option for managing end stage OA. However, patient selection is crucial, and factors such as age, comorbidities, and obesity must be considered to optimize outcomes. Total joint arthroplasty remains the gold standard for surgical management of severe OA, offering substantial benefits in pain relief and functional improvement. Other surgical options, such as osteotomies and arthroscopy, have limited roles and should be considered based on individual patient factors and disease severity. Evidence-based guidelines support the timely use of TJA to enhance patient outcomes and quality of life.
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Registered trials
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