Evidence map›Paper›PMID 40406183›Full record

ArticleTransplantation direct2025

Vasopressin Is Not Associated With Severe Kidney Injury in Liver Transplantation: A Propensity Score-adjusted Analysis.

Edoardo Antonucci, Michael P Bokoch, Dieter Adelmann, Kerstin Kolodzie, Garrett R Roll, Elizabeth Sun, Matthieu Legrand, Rishi Kothari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edoardo AntonucciDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.ORCID https://orcid.org/0000-0001-7031-779X
Michael P BokochDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Dieter AdelmannDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Kerstin KolodzieDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Garrett R RollDivision of Transplant Surgery, Department of Surgery, University of California, San Francisco, CA.
Elizabeth SunDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Matthieu LegrandDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.
Rishi KothariDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA.ORCID https://orcid.org/0000-0002-7148-970X

Funding

The choice of vasopressor to prevent postoperative acute kidney injury after major non-cardiac surgery: a multicenter pragmatic cluster cross-over randomized trial (the VEGA-2 trial)R01DK139484 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SACHIN KHETERPAL, Matthieu Legrand · 2024 to 2026
$2.0M
NIDDK NIH HHS R01 DK139484
6 · The paper itself

Abstract

Background: Hypotension during liver transplantation often requires vasopressor therapy. Acute kidney injury is a common complication after liver transplantation. Vasopressin acts as a portal flow modulator, may increase the glomerular filtration rate, and reduce the dose of catecholamines required. We hypothesized that intraoperative vasopressin use could be associated with reduced postoperative acute kidney injury. Methods: This single-center retrospective cohort study included 1120 adult liver transplant recipients between June 2012 and November 2022. We assessed the association between intraoperative vasopressin use and postoperative severe acute kidney injury by using a propensity score-adjusted multivariable regression model. Results: The incidence of severe postoperative acute kidney injury was 29.2%. The median age was 60 y, 64.9% of patients were males. Vasopressin was used in 34.0% of the cases. Patients receiving vasopressin had a higher Model for End-Stage Liver Disease-sodium score (24 versus 16, Conclusions: In patients requiring high doses of intraoperative vasopressors during liver transplantation, vasopressin use was not associated with an increased risk of severe postoperative acute kidney injury or decreased graft survival.

Identifiers

PMID40406183
PMCPMC12097770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.