Evidence map›Paper›PMID 40406167›Full record

ArticleMaternal-fetal medicine (Wolters Kluwer Health, Inc.)2024

Breast Milk Application as a Natural Method for Umbilical Cord Care: A Community-Label 3-Arm Pilot Clinical Trial.

Bekalu Kassie Alemu, Leltework Yismaw Wondimagegn, Yibelu Bazezew, Tewachew Muche Liyeh, Abebaw Abeje Muluneh, Gedefaye Nibret Mihretie, Alekaw Sema, Melese Linger Endalifer, Getnet Gedefaw Azeze, Gashaw Garedew Woldeamanuel and 4 more

Abstract read
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In one paragraph

Article in Maternal-fetal medicine (Wolters Kluwer Health, Inc.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bekalu Kassie AlemuDepartment of Midwifery, College of Medicine and Health Sciences, Debre Markos University, Debre Markos 269, Ethiopia.ORCID https://orcid.org/0000-0002-9719-6331
Leltework Yismaw WondimagegnDepartment of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos 269, Ethiopia.
Yibelu BazezewDepartment of Midwifery, College of Medicine and Health Sciences, Debre Markos University, Debre Markos 269, Ethiopia.
Tewachew Muche LiyehDepartment of Midwifery, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor 272, Ethiopia.
Abebaw Abeje MulunehDepartment of Midwifery, College of Medicine and Health Sciences, Debre Markos University, Debre Markos 269, Ethiopia.
Gedefaye Nibret MihretieDepartment of Midwifery, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor 272, Ethiopia.
Alekaw SemaDepartment of Midwifery, College of Medicine and Health Sciences, Dire-Dawa University, Dire-Dawa 1362, Ethiopia.
Melese Linger EndaliferDepartment of Human Nutrition, College of Medicine and Health Sciences, Debre Markos University, Debre Markos 269, Ethiopia.
Getnet Gedefaw AzezeDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.
Gashaw Garedew WoldeamanuelDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.
Kenean Getaneh TlayeDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.
Wing Fong LeeDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.
Yao WangDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.ORCID https://orcid.org/0000-0003-0010-2819
Chi Chiu WangDepartment of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To compare the effects of human breast milk with those of chlorhexidine and the dry method on umbilical cord separation in Ethiopia. Methods: This open-label 3-arm nonrandomized pilot clinical trial was conducted among 45 neonates (15 in each arm) with more than 630 home visits. After a standard cord cut, human breast milk, chlorhexidine, or nothing was applied once per day for 7 days. The primary outcome was the duration of cord separation, while the secondary outcomes were umbilical cord infection, neonatal fever, jaundice, feeding and breathing difficulty, and persistent crying. Results: There were statistically significant differences in the time-to-cord separation between the human breast milk group and the chlorhexidine ( Conclusion: This community-label study indicated that human breast milk application significantly shortened the length of umbilical cord separation time compared to chlorhexidine and dry methods. A large-scale randomized controlled trial is needed to confirm these results. Registration: PACTR202310902873290; https://pactr.samrc.ac.za.

Indexed as

ChlorhexidineHuman breast milkNeonatal careTrialUmbilical cord

Identifiers

PMID40406167
PMCPMC12094378

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.