Catalpol inhibits Hedgehog signaling pathway to suppress proliferation and promote lipid accumulation in rat meibomian gland epithelial cells.

Zibin Liu, Rui Zhang, Jian Lai

Abstract read

In one paragraph

Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zibin LiuDepartment of Ophthalmology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, No. 453, Stadium Road, Hangzhou, 310007 Zhejiang China.

Rui ZhangDepartment of Ophthalmology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, No. 453, Stadium Road, Hangzhou, 310007 Zhejiang China.

Jian LaiDepartment of Ophthalmology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, No. 453, Stadium Road, Hangzhou, 310007 Zhejiang China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meibomian gland dysfunction (MGD) is an ocular surface disease lacking optimal treatment strategy. The Hedgehog pathway is involved in regulating MGEC proliferation and differentiation. Catalpol (CAT) is the main active ingredient in Supplementary Information: The online version contains supplementary material available at 10.1007/s10616-025-00769-9.

Indexed as

3T3 cellCatalpolMeibomian gland dysfunctionMeibomian gland epithelial cellsPrimary culture

Identifiers

PMID40406032

DOI10.1007/s10616-025-00769-9

PMCPMC12092864

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.