ArticleGland surgery2025
Serum thyroid-stimulating hormone as a diagnostic marker for cancer in atypia of undetermined significance/follicular lesion of undetermined significance nodules.
Article in Gland surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Several studies have assessed the efficacy of thyroid-stimulating hormone (TSH) as a diagnostic marker of thyroid cancer (TC), with inconsistent findings. However, few studies have investigated its role in indeterminate thyroid nodules (TNs), particularly in those with atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS). The objective of this study was to evaluate preoperative TSH levels as a diagnostic marker for cancer in AUS/FLUS nodules. Methods: A retrospective analysis was conducted on patients who underwent thyroidectomy with a primary cytological diagnosis of AUS/FLUS. The association between preoperative TSH levels and the final anatomopathological diagnosis (benign Results: The analysis included 109 patients. The median TSH level was higher in patients with malignant nodules (2.32 mIU/L) than in those with benign pathology (1.60 mIU/L) (P=0.04). Receiver operating characteristic (ROC) curve analysis revealed that the TSH level was a potential indicator for the coexistence of thyroid malignancy, with a significant area under the curve of 0.61 (P=0.04). The optimal diagnostic cutoff point for TSH levels was ≥3.06 mIU/L. Conclusions: This study demonstrated that TSH levels are an acceptable and useful marker to rule in rather than rule out TC in AUS/FLUS nodules.
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