Evidence map›Paper›PMID 40405883›Full record

ArticleFrontiers in psychiatry2025

Relationships between depersonalization-derealization symptoms and separation anxiety in adult patients with mood and anxiety disorders.

Stefano Pini, Benedetta Nardi, Barbara Carpita, Giada Lorenzi, Marco Mula, Barbara Milrod, Gabriele Massimetti, Ivan M Cremone, Chiara Bonelli, Katharina Domschke and 3 more

Abstract read
In one paragraph

Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stefano PiniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Benedetta NardiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Barbara CarpitaDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Giada LorenziDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Marco MulaInstitute of Medical and Biomedical Education, St George's University Hospitals National Health Service (NHS) Foundation Trust and City St George's University of London, London, United Kingdom.
Barbara MilrodAlbert Einstein College of Medicine, PRIME (Psychiatric Research Institute of Montefiore Einstein), New York, NY, United States.
Gabriele MassimettiDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Ivan M CremoneDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Chiara BonelliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Katharina DomschkeDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Miriam SchieleDepartment of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Liliana Dell'OssoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
David S BaldwinClinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: To establish the relationship between depersonalization/derealization symptoms (DPs), as assessed by different standardized DP scales, and separation anxiety in a sample of outpatients with anxiety and mood disorders as a primary diagnosis (n=156). We hypothesized that patients with high levels of separation anxiety had more frequent, severe, and clinically relevant DP symptoms than those with low levels of separation anxiety. Methods: A consecutive sample of 156 outpatients with mood and anxiety disorders was evaluated by the Structured Clinical Interview for Derealization/Depersonalization Spectrum (SCI-DER), the Cambridge Depersonalization Scale (CDS), the Body Sensation Questionnaire (BSQ), the Dissociative Experience Scale (DES), the Panic/Agoraphobic Questionnaire-self report (PAS-SR) for the evaluation of separation anxiety. Results: The sample was dichotomized into a group with high levels of separation anxiety (3 or more DSM-IV diagnostic items endorsed) Conclusions: Our findings highlight a link between separation anxiety and DP symptoms. This connection contributes to understanding and evaluating suicidality in individuals with mood and anxiety disorders.

Indexed as

adult separation anxietydepersonalizationderealizationdissociative symptomsseparation anxietysuicidality

Identifiers

PMID40405883
PMCPMC12095167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.