Evidence map›Paper›PMID 40405701›Full record

ArticlePlatelets2025

Pharmacodynamic effects of early aspirin withdrawal after percutaneous coronary intervention in patients with atrial fibrillation treated with ticagrelor or prasugrel.

Mark A Sammut, Mohammed E F Rahman, Claire Bridge, Jessica Hanson, Heather Judge, Bethany Lynch, Emily Maz, Hannah McMellon, Janet Middle, Georgia Williamson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Platelets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mark A SammutDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.ORCID 0000-0003-3756-4726
Mohammed E F RahmanDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Claire BridgeDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Jessica HansonDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Heather JudgeDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Bethany LynchDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Emily MazDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Hannah McMellonDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Janet MiddleDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Georgia WilliamsonDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
William A E ParkerDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.ORCID 0000-0002-7822-8852
Justin LeeSouth Yorkshire Cardiothoracic Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
Robert F StoreyDivision of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dual antithrombotic therapy (DAT) without aspirin reduces bleeding compared with triple antithrombotic therapy (TAT) in patients with atrial fibrillation who have undergone percutaneous coronary intervention, without apparently increasing ischemic events. A prospective pharmacodynamic study was performed to investigate the impact of aspirin on bleeding time, platelet function and fibrin clot analysis in this population. Patients receiving TAT (

Indexed as

AspirinAtrial FibrillationPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrasugrel HydrochlorideTicagrelorAgedFemaleHumansMaleMiddle AgedProspective StudiesAspirinPlatelet Aggregation InhibitorsPrasugrel HydrochlorideTicagrelorAcute coronary syndromeaspirinatrial fibrillationdual antithrombotic therapyticagrelortriple antithrombotic therapy

Identifiers

PMID40405701
PMCPMC12309453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.