Evidence map›Paper›PMID 40405656›Full record

ArticleKorean journal of orthodontics2025

Bisphenol A release in the saliva of children with Haas expanders.

Viviane Oliveira Prado, Maria Eugenia Queiroz Nassur, Israel D Souza, Paulo Nelson-Filho, Karla Carpio Horta, Fábio Lourenço Romano, Ana Paula Valladares de Almeida, Caio Luiz Bitencourt Reis, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto

Abstract read
In one paragraph

Article in Korean journal of orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Viviane Oliveira PradoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0002-9921-5479
Maria Eugenia Queiroz NassurDepartment of Chemistry, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0002-0172-1884
Israel D SouzaDepartment of Chemistry, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0003-0237-6282
Paulo Nelson-FilhoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0001-8802-6480
Karla Carpio HortaEdmonton Clinic Health Academy, University of Alberta, Edmonton, AB, Canada.ORCID https://orcid.org/0000-0002-1006-9592
Fábio Lourenço RomanoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0003-1419-3520
Ana Paula Valladares de AlmeidaDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0001-8414-1334
Caio Luiz Bitencourt ReisDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0003-0606-1632
Maria Bernadete Sasso StuaniDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0001-7791-9144
Mirian Aiko Nakane MatsumotoDepartment of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.ORCID https://orcid.org/0000-0001-8559-8715

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Several studies have highlighted the toxic potential of bisphenol A (BPA), however, BPA release from orthopedic devices remains poorly investigated. Therefore, this study aimed to evaluate BPA levels in the saliva of children treated using Haas expanders. Methods: Twenty-two children of both sexes aged 6-10 years who required rapid maxillary expansion were recruited. One week after placement of elastics to separate the permanent molars, orthodontic bands were adapted, and maxillary impressions were obtained using alginate impression material. Haas expanders were fabricated using a standardized amount of acrylic resin. The bands were cemented using Transbond Plus Light Cure Band (3M). Saliva samples were collected at five time points: before (T0) and 30 minutes (T1), 24 hours (T2), 1 week (T3), and 1 month (T4) after Haas expander installation. BPA levels were measured using ultra-high-performance liquid chromatography coupled with Tandem Mass Spectrometry. The results were evaluated using one-way analysis of variance with Tukey's post-hoc test (alpha = 5%). Results: BPA levels were below the recommended tolerable daily intake (TDI) at all timepoints; however, salivary BPA levels at T1 (70.324 ng/mL ± 37.05) and at T2 (18.015 ng/mL ± 11.22) were significantly higher compared to that at T0 (0.475 ng/mL ± 0.27) ( Conclusions: Salivary BPA levels significantly increased 30 minutes and 24 hours after Haas expander installation and return to baseline values after 1 week. BPA levels did not exceed the TDI, suggesting that the use of Haas expanders may be considered safe concerning BPA exposure in children.

Indexed as

AdhesiveAppliancesBiocompatibilityExpansion

Identifiers

PMID40405656
PMCPMC12100336

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.