Evidence map›Paper›PMID 40405544›Full record

ArticleAnatomy & cell biology2025

A potential interference of chemoreception in inflamed vomeronasal organ with experimental autoimmune encephalomyelitis.

Kyungsook Jung, Deokho Ko, Sungmoo Hong, Irene Ortiz-Leal, Pablo Sanchez-Quinteiro, Meejung Ahn, Changjong Moon, Taeyoung Kang, Taekyun Shin, Jeongtae Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anatomy & cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kyungsook JungFunctional Biomaterials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Korea.ORCID https://orcid.org/0000-0002-0723-805X
Deokho KoDepartment of Veterinary Medicine, Graduate School and Veterinary Medical Research Institute, Jeju National University, Jeju, Korea.ORCID https://orcid.org/0009-0006-9357-0855
Sungmoo HongDepartment of Veterinary Medicine, Graduate School and Veterinary Medical Research Institute, Jeju National University, Jeju, Korea.ORCID https://orcid.org/0009-0007-3906-3526
Irene Ortiz-LealDepartment of Anatomy, Animal Production and Clinical Veterinary Sciences, Faculty of Veterinary, University of Santiago de Compostela, Lugo, Spain.ORCID https://orcid.org/0000-0002-8468-3659
Pablo Sanchez-QuinteiroDepartment of Anatomy, Animal Production and Clinical Veterinary Sciences, Faculty of Veterinary, University of Santiago de Compostela, Lugo, Spain.ORCID https://orcid.org/0000-0002-9891-4817
Meejung AhnDepartment of Anatomy and Cell Biology, College of Medicine, Chungnam National University, Daejeon, Korea.ORCID https://orcid.org/0000-0002-7302-9694
Changjong MoonCollege of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju, Korea.ORCID https://orcid.org/0000-0003-2451-0374
Taeyoung KangDepartment of Veterinary Obstetrics, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, Korea.ORCID https://orcid.org/0000-0002-2591-9713
Taekyun ShinDepartment of Veterinary Medicine, Graduate School and Veterinary Medical Research Institute, Jeju National University, Jeju, Korea.ORCID https://orcid.org/0000-0002-9851-4354
Jeongtae KimDepartment of Anatomy, Jeju National University College of Medicine, Jeju, Korea.ORCID https://orcid.org/0000-0003-2238-1038

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation of the vomeronasal organ (VNO) was evaluated in the context of experimental autoimmune encephalomyelitis (EAE). The VNO was sampled in mice with myelin oligodendrocyte glycoprotein-induced EAE, and processed for paraffin embedding. The sections were immunohistochemically evaluated for various markers, including ionized calcium binding adaptor molecule 1 (Iba1), myeloperoxidase (MPO), and olfactory marker protein (OMP). Inflammatory cell infiltration was detected in the connective tissues. Both Iba1-positive macrophages and MPO-positive neutrophils infiltrated the VNO of EAE, with increased secretion of mucus into the lumen. The intensity of the OMP-positive immunoreaction was decreased in the vomeronasal sensory epithelium of EAE-induced mice. We postulate that the inflammatory response of the VNO in EAE is associated with dysfunction of the accessory olfactory system.

Indexed as

Experimental autoimmune encephalomyelitisMacrophagesMyeloperoxidaseOlfactory marker proteinVomeronasal organ

Identifiers

PMID40405544
PMCPMC12519011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.