ArticleAcute and critical care2025
Excessive fluid resuscitation is associated with intensive care unit mortality in Pakistani patients with dengue shock syndrome.
Article in Acute and critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Unveiling the molecular mechanism of Qingwen Baidu decoction against dengue fever: an integrated study of bioinformatic analysis, machine learning and network pharmacology.Functional & integrative genomics · 2026Article
- Integrating structured point-of-care ultrasound into dengue fever management: A mini review and comprehensive clinical guide.World journal of critical care medicine · 2026Review
- The fluid challenge: Evaluating supportive care in dengue through radiological and clinical markers.Bioinformation · 2026Article
- Comment on "Excessive fluid resuscitation is associated with intensive care unit mortality in Pakistani patients with dengue shock syndrome".Acute and critical care · 2025Article
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6 authors.
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Abstract
backgroundThe mortality of severe dengue infections is approximately 23%. In the management of dengue shock syndrome (DSS), aggressive fluid resuscitation is recommended. The primary objective of our study was to assess the factors associated with 30-day mortality in DSS patients.
methodsAdult patients >18 years old, who were admitted with DSS were included. DSS was diagnosed in patients who required vasopressors or had lactic acidosis >4 mmol/L. Patients were divided into three different groups based on cumulative fluid balance at death or extubation: group I (<3.5 L), group II (3.5-8.0 L), and group III (>8.0 L).
resultsA total of 135 patients with DSS was included, with an overall 30-day mortality of 74.8%. The average Sequential Organ Failure Assessment (SOFA) score on intensive care unit admission was 12.2. Mechanical ventilation was required in 112 patients (83.0%), with 61 patients (45.2%) being intubated without a noninvasive ventilation trial. Respiratory failure was the most common reason for requiring intubation (65 patients, 48.2%). In survivors, the median cumulative fluid balance was 1,493 ml (interquartile range [IQR], 0-4,501 ml), whereas that in the mortality group was 7,797 ml (IQR, 3,700-13,600 ml). On multivariate analysis, SOFA score (odds ratio [OR], 1.220; 95% CI, 1.011-1.472; P=0.038) and having received >8.0 L cumulative fluid balance (OR, 6.682; 95% CI, 1.808-24.689; P=0.004) were associated with increased risk of mortality.
conclusionsDSS patients have high mortality rates. High SOFA scores and >8.0 L cumulative fluid balance may indicate worse outcomes.
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