Comparison of Long-Term Air Pollution Exposure from Mobile and Routine Monitoring, Low-Cost Sensors, and Dispersion Models.

introductionAssessment of long-term exposure to outdoor air pollution remains a major challenge for epidemiological studies. One of these challenges is characterizing fine-scale spatial variation of the ambient concentrations of key traffic-related air pollutants - including ultrafine particles (UFPs), black carbon (BC), and nitrogen dioxide (NO The Specific Aims of the study. 1. Develop long-term ambient air pollution exposure estimates for selected epidemiological studies based on low-cost sensors, mobile and fixed-site monitoring, and deterministic dispersion modeling. 2. Compare different exposure assessment methods in terms of their ability to predict spatial variation of long-term average concentrations using external validation data. 3. Compare different exposure assessment methods in terms of air pollution effect estimates in selected epidemiological studies. We assessed UFPs, NO

methodsWe evaluated annual average air pollution concentrations across the Netherlands using a suite of different exposure models, which differed in modeling approach (empirical LUR, deterministic dispersion models) and monitoring data used (low-cost sensors, mobile monitoring, nationwide and Europewide routine monitoring, and study-specific targeted monitoring). For empirical models, we tested three model development algorithms: supervised linear regression (SLR), Random Forest, and least absolute shrinkage and selection operator (LASSO). The predictions of the models were compared at 20,000 addresses across the Netherlands. The performance was also tested on external validation data, which were obtained from a new campaign (2021-2023) and existing data from different years, allowing assessment of how well recent models predict past air pollution exposure. Epidemiological analyses in three cohort studies were conducted to compare health effect estimates of the different exposure models. We assessed associations of air pollution in a national administrative cohort with natural-cause and cause-specific mortality, in a cohort study that had detailed lifestyle data with natural-cause mortality and incidence of stroke and coronary events, and in a mature birth cohort with lung function and asthma incidence.

resultsExposure predictions at residential sites from the dispersion model and the Europewide hybrid LUR models were available for multiple years in the period 2010-2019. For these models, exposure predictions of different years in the period 2010-2019 were highly correlated for BC, NO The exposure models generally resulted in highly to moderately correlated exposure predictions at residential sites across the Netherlands (R > 0.7 for BC, NO Consistent with the high correlation of the different exposure models, the application of these models generally resulted in similar conclusions on the presence of associations with natural-cause, respiratory, and lung cancer mortality in the large nationwide cohort, and with asthma incidence and lung function in the birth cohort. However, the effect estimates differed substantially; for example, the HR for natural-cause mortality in the nationwide administrative cohort for a 1 µg/m Differences in exposure assessment may contribute substantially to the observed heterogeneity of effect estimates in systematic reviews of epidemiological studies. High heterogeneity was indicated by the commonly used heterogeneity measure I Validation of long-term exposure models for the nonroutinely monitored pollutants BC and especially UFPs was challenging, despite generally successful monitoring. The new external validation monitoring campaign resulted in rather unstable estimates of the long-term average spatial contrast, both across sites and where affected by temporal variation, especially for BC and PM No consistent differences were found in the model performance of SLR, Random Forest, and LASSO, both in internal cross-validation of model building and on external validation sites not used in model building. Exposure predictions from the three algorithms were generally highly correlated and resulted in similar associations with health. However, for individual models, occasionally large differences were found in exposure contrast, validation statistics, and associations with mortality and morbidity outcomes. There was little benefit in using low-cost sensors for NO

conclusionsThe main conclusions of the project. • Exposure predictions of BC, NO • Models explained historical exposure patterns at external sites covering more than 10 years moderately well, especially for BC. • Different exposure models generally resulted in highly to moderately correlated exposure predictions. The predicted level of exposure and exposure contrast could differ substantially between models. Small differences were found between the different models in explaining spatial variation at validation sites. • Application of different exposure models resulted in similar conclusions about the presence of associations with health outcomes, but effect estimates differed substantially in magnitude between individual exposure models. No consistent differences in effect estimates were found between groups of mobile, dispersion, and fixed-site LUR models. • Differences in exposure models may therefore contribute substantially to the observed heterogeneity of effect estimates in systematic reviews of epidemiological studies. Factors that explained some of the heterogeneity of effect estimates included the performance of the model at external validation sites and the predicted exposure contrast. • Exposure predictions from the three algorithms were generally highly correlated and resulted in similar associations with health. No consistent differences were found in their model performances.