Evidence map›Paper›PMID 40405277›Full record

ArticleCell & bioscience2025

AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway.

Aru Su, Linghui Pan, Qian Zhou, Qin Zhu, Ruihua Li, Mingming Liu, Ruifan Wu, Lina Wang, Songbo Wang, Qingyan Jiang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aru Su *State Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Linghui Pan *State Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Qian ZhouState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Qin ZhuState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Ruihua LiState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Mingming LiuState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Ruifan WuState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Lina WangState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Songbo WangState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Qingyan JiangState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China.
Gang ShuState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China. shugang@scau.edu.cn.
Canjun ZhuState Key Laboratory of Swine and Poultry Breeding Industry, Province Key Laboratory of Animal Nutritional Regulation and Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, Guangdong, China. canjunzhu@scau.edu.cn.

Funding

National Natural Science Foundation of China 32102626National Natural Science Foundation of China 32272954National Natural Science Foundation of China 32372968National Natural Science Foundation of China U21A20245-3
6 · The paper itself

Abstract

Obesity poses serious health risks and is trending younger, developing effective strategies to prevent obesity is crucial. Calcium intake is a potential strategy to reduce weight/fat, as it generally enhances the body's energy metabolism. However, calcium's effects on appetite and its specific mechanisms remain unclear. To investigate these questions, we administered calcium orally to fasted mice and found that calcium inhibited food intake during the first 3 h. Long-term calcium supplementation in water decreased HFD intake, weight gain, and fat deposition while increasing energy metabolism in young mice. Mechanistically, calcium activated the vagal afferent nerves and inhibited ARC

Indexed as

AgRPAppetiteCalciumVagal afferent nerve

Identifiers

PMID40405277
PMCPMC12096759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.