Evidence map›Paper›PMID 40405264›Full record

ArticleChinese medicine2025

Modulation of lung CD11b

Mi Cheng, Pan-Pan Shang, Dan-Dan Wei, Jie Long, Xue Zhang, Quan-Long Wu, Gabriel Shimizu Bassi, Yu Wang, Yan-Jiao Chen, Lei-Miao Yin and 2 more

Erratum issuedAbstract read
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In one paragraph

Article in Chinese medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
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  6. Review
  7. Correction: Modulation of lung CD11bChinese medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Mi Cheng *Shanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Pan-Pan Shang *Shanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dan-Dan Wei *Shanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jie LongShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xue ZhangShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Quan-Long WuShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Gabriel Shimizu BassiShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yu WangShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yan-Jiao ChenShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Lei-Miao YinShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yong-Qing YangShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. yyq@shutcm.edu.cn.
Yu-Dong XuShanghai Research Institute of Acupuncture and Meridian,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. xuyudong@shutcm.edu.cn.ORCID http://orcid.org/0000-0002-9705-8895

Funding

Natural Science Foundation of China 81973952Natural Science Foundation of China 82105013Natural Science Foundation of China 82374583
6 · The paper itself

Abstract

backgroundAllergic asthma features Th2-mediated airway inflammation, with dendritic cells (DCs) playing a crucial role. Acupuncture shows promise in modulating immune responses, yet its mechanisms in allergic asthma are not well understood. This study explores how acupuncture alleviates Th2 airway inflammation by modulating lung CD11b

methodsFemale BALB/c mice were assigned to control and asthma model groups, with subsets receiving acupuncture at Dazhui (GV14), Fengmen (BL12), and Feishu (BL13). We evaluated airway hyperresponsiveness (AHR), immune cell infiltration, histological changes, Th2 cytokine production, and serum IgE levels. The effects of acupuncture serum on T cell activation and bone marrow-derived dendritic cells (BMDCs) were assessed. The role of CD11b

resultsAcupuncture significantly reduced AHR, immune cell infiltration, goblet cell hyperplasia, and serum IgE levels in HDM-induced allergic asthma. It also suppressed Th2 cytokine production and differentiation. While acupuncture serum did not directly affect T cell activation, it modulated BMDC activity. Adoptive transfer of acupuncture-treated lung DCs into asthmatic mice reduced Th2 cell recruitment and ameliorated airway inflammation. Acupuncture reduced the population of lung CD11b

conclusionsAcupuncture alleviates Th2 airway inflammation in allergic asthma by modulating lung CD11b

Indexed as

AcupunctureAirway epitheliumAlarmin cytokinesAllergic asthmaDendritic cellsImmunoregulationTh2 cellType 2 innate lymphoid cells

Identifiers

PMID40405264
PMCPMC12100888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.