Evidence map›Paper›PMID 40405232›Full record

ArticleBMC chemistry2025

Molecular hydrogen mitigates traumatic brain injury-induced lung injury via NLRP3 inflammasome inhibition.

Lingling Liu, Shuzhi Wang, Lianhao Jiang, Jiwei Wang, Jun Chen, Hongtao Zhang, Yuanlin Wang

Abstract read
In one paragraph

Article in BMC chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingling LiuDepartment of Anesthesiology, Tianjin Huanhu Hospital, NO. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
Shuzhi WangDepartment of Cardiac Function, Tianjin Thoracic Hospital, Tianjin Institute of Cardiovascular Diseases, Tianjin, 300222, China.
Lianhao JiangDepartment of Anesthesiology, Tianjin Huanhu Hospital, NO. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
Jiwei WangTianjin Key Laboratory of Cerebral Vascular and Neurodegenrative Diseases, Tianjin, 300350, China.
Jun ChenDepartment of Anesthesiology, Tianjin Huanhu Hospital, NO. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China.
Hongtao ZhangDepartment of Anesthesiology, Tianjin Huanhu Hospital, NO. 6 Jizhao Road, Jinnan District, Tianjin, 300350, China. zhanght80@126.com.
Yuanlin WangDepartment of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital, No. 154 Anshan Rd, Heping District, Tianjin, 300052, China. wyl1996@tmu.edu.cn.

Funding

National Natural Science Foundation of Tianjin No.20JCQNJC01270
6 · The paper itself

Abstract

introductionHydrogen gas has demonstrated significant antioxidant and anti-inflammatory properties, suggesting potential therapeutic benefits in TBI.

methodsWe subjected to controlled cortical impact in mice to construct TBI model. They received an intraperitoneal injection of MCC950, a selective NLRP3 inhibitor, at 10 mg/kg 30 min before TBI. Inhalation of 2% H

resultsSignificant lung injury at 24 h post-TBI got significantly reduced by treatment of 2% H

conclusions2% H

Indexed as

Hydrogen gasLung injuryNLRP3 inflammasomeTraumatic brain injury

Identifiers

PMID40405232
PMCPMC12100871

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.