Evidence map›Paper›PMID 40405218›Full record

ArticleCell communication and signaling : CCS2025

EMT induction in normal breast epithelial cells by COX2-expressing fibroblasts.

Minwoo Kang, Somayadineshraj Devarasou, Nam Ji Sung, Tae Yoon Kwon, Jennifer H Shin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minwoo KangDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea.
Somayadineshraj DevarasouDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea.
Nam Ji SungDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea.
Tae Yoon KwonDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea.
Jennifer H ShinDepartment of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-Ro, Yuseong-Gu, Daejeon, 34141, Republic of Korea. j_shin@kaist.ac.kr.

Funding

Korean Fund for Regenerative Medicine (KFRM) grant, funded by the Korea government (the Ministry of Science and ICT, the Ministry of Health & Welfare) (22B0401L1)National Research Foundation of Korea NRF-2021R1A2C3008408
6 · The paper itself

Abstract

backgroundThe tumor microenvironment (TME) plays a pivotal role in cancer progression, with cancer-associated fibroblasts (CAFs) significantly influencing tumor behavior. Especially, elevated COX2 expressing fibroblasts within the TME, notably in collagen-dense tumors like breast cancer, has been recently emphasized in the literature. However, the specific effect of COX2-expressing CAFs (COX2

methodsWe induced COX2

resultsOur in vitro findings demonstrate that COX2

conclusionThis study advances our understanding of the potential mechanisms by which COX2

Indexed as

BreastEpithelial CellsEpithelial-Mesenchymal TransitionFibroblastsAnimalsCell LineCyclooxygenase 2DinoprostoneRatsReceptors, Prostaglandin E, EP4 SubtypeSignal TransductionCyclooxygenase 2DinoprostonePtgs2 protein, ratReceptors, Prostaglandin E, EP4 SubtypeBreast cancerCancer-associated fibroblastsCOX2EMTFibroblastsNemosisPGE2Tumor microenvironment

Identifiers

PMID40405218
PMCPMC12100922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.