Trial reportBMC oral health2025
The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota composition in individuals with stage III-IV periodontitis: a randomized controlled trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Effects of Non-Surgical Periodontal Therapy on Gingival Crevicular Fluid Apelin Isoforms and Oxidative Stress Markers in Periodontitis.Diagnostics (Basel, Switzerland) · 2026Article
- Adjunctive Therapies in Periodontitis: Current Concepts and the Future.Journal of periodontal research · 2026Review
- Review
- Subgingival microbiome and adjunctive use of probiotics in the treatment of periodontitis in patients with diabetes: a secondary analysis of a randomized clinical trial.Journal of oral microbiology · 2026Article
- The role of probiotics in controlling oral biofilm formation and mitigating oral squamous-cell carcinoma risk.Archives of microbiology · 2025Review
- Quorum-Quenching AHL-Lactonase Est816 Inhibits Polymicrobial Subgingival-Plaque-Derived Biofilm Formation.Dentistry journal · 2025Article
- Effects of Probiotics as an Adjunct to Non-Surgical Periodontal Therapy (NSPT): A Narrative Review.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe clinical and microbiological outcomes of probiotic-assisted periodontal therapy remain inconclusive in prior research. This ambiguity may stem from uncertainties regarding the duration, dosage, and administration route of probiotics. Additionally, earlier studies predominantly concentrated on the identification of individual bacterial species, thereby limiting the ability to thoroughly elucidate the intricate composition of microbial communities and the synergistic or antagonistic interactions among their constituents. The study aimed to investigate the effect of combining probiotics with non-surgical periodontal therapy on clinical and microbiota changes in patients with stage III-IV periodontitis.
methodsA total of 40 patients were randomized into two groups to receive non-surgical periodontal treatment. The test group received Limosilactobacillus reuteri for 21 days along with treatment. Periodontal indicators were examined at baseline and 1 and 6 months after treatment. Saliva and subgingival biofilm samples were collected for 16 S rRNA gene sequencing analysis.
resultsAfter treatment, both groups showed significant improvements in clinical parameters. In the test group, attachment loss and the medium pocket were significantly reduced at 6 months compared to that at 1 month. The presence of Tannerella forsythia in subgingival biofilms decreased significantly in the test group after treatment. Among salivary microorganisms, the abundance of Prevotella nanceiensis significantly increased in both groups, while that of Streptococcussp. was significantly reduced in the control group. Linear discriminant analysis indicated that the most significant distinction between the groups was observed in the subgingival biofilm samples 1 month after treatment.
conclusionsCombining L. reuteri with non-surgical periodontal therapy may not directly improve clinical indicators. The treatment showed potential benefits by changing the microbial composition of subgingival biofilm and enhancing treatment sensitivity.
trial registrationThe trial was approved by the Chinese Clinical Trial Registry (ChiCTR) on March 25, 2021, with registration number ChiCTR2100044638.
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