ArticleBMC biotechnology2025
Bio-induced overproduction of heterocycloanthracin-like bacteriocin in Lysinibacillus macroides by Aspergillus austroafricanus: optimization of medium conditions and evaluation of potential applications.
Article in BMC biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPlants and microorganisms are at the forefront of natural exploitable bioresources for the discovery of novel bioactive compounds (BACs) to provide solutions to food and agricultural challenges. The present study aimed to produce a novel biotechnologically-relevant BAC from a mangrove sediment bacterium under optimized bioprocess medium conditions. The BAC-producing bacteria were isolated via the crowded plate technique, and medium optimization was performed via sequential statistics of response surface methodology (RSM). The RSM model predictions were optimized, validated, and scaled up in a 5-L bioreactor via submerged batch fermentation. The BAC was extracted with ethyl acetate, purified via silica gel column chromatography, and identified via semipreparative high-performance liquid chromatography using bioactive standards with known retention times. The biocontrol, antioxidant and biopreservation potential of the BAC were evaluated via standard methods.
resultsThe results revealed that strain GKRMS-A9 produced the largest inhibition zone diameter (ZND) of 17 mm against the susceptible mould. The bacterium and its susceptible mould were identified as Lysinibacillus macroides and Aspergillus austroafricanus strains, respectively. Bioprocess medium optimization produced 9.6 g L
conclusionThe bacteriocin 'macroidin' is stable over a wide range of pH values and temperatures and has significant antimicrobial activity against Gram-positive food-borne and phytopathogenic strains of bacteria and moulds. Its antioxidant activities against DPPH and ABTS*
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