Evidence map›Paper›PMID 40405116›Full record

ArticleBMC infectious diseases2025

HPV-associated squamous cell carcinoma and adenocarcinoma in distinct cervical sites: a case report.

Huihui Chen, Qingyi Wang, Min Kang, Wei Huang, Hao Zhang, Jiaxin Li, Donghan Xu, Lin Zhao, Bowen Wu, Xin Lin and 6 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Huihui Chen *Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Qingyi Wang *Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 208 Yuehua Road, Xiangzhou District, Zhuhai, 519000, Guangdong province, China.
Min Kang *Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 208 Yuehua Road, Xiangzhou District, Zhuhai, 519000, Guangdong province, China.
Wei HuangZhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 208 Yuehua Road, Xiangzhou District, Zhuhai, 519000, Guangdong province, China.
Hao ZhangFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Jiaxin LiFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Donghan XuFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Lin ZhaoFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Bowen WuFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Xin LinFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Liqi LiFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Yuhong ZhengFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Yihao NiuFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780.
Jiaqi ZhouHaploX Biotechnology, 8th Floor, Aotexun Electric Power Building, No. 3 Son-gpingsha n Road, Gaoxin North District, Nanshan District, Shenzhen, Guangdong Province, 518000, China.
Donghui HuangZhuhai Hospital of Integrated Traditional Chinese and Western Medicine, 208 Yuehua Road, Xiangzhou District, Zhuhai, 519000, Guangdong province, China. 13600001163@139.com.
Peiyu YanFaculty of Chinese Medicine, Macau University of Science and Technology, Macau, China, 999780. pyyan@must.edu.mo.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe synchronous occurrence of adenocarcinoma and squamous cell carcinoma in distinct cervical regions is exceptionally rare. This report highlights a case of HPV-associated adenocarcinoma and squamous cell carcinoma at distinct sites in a patient with primary stage IA1 cervical cancer. CASE PRESENTATION: A 54-year-old female tested HPV type 18 positive in a routine physical exam. Cervical Liquid - based Cytology Test (LCT) showed Atypical Squamous Cells of Undetermined Significance (ASCUS). Colposcopy-directed biopsies revealed moderately differentiated squamous cell carcinoma at multiple sites (3, 6, 9, 12 o'clock positions and the ECC), with a clinical diagnosis of stage IA1. Preoperative abdominal MRI (including contrast enhancement) showed no lymph node enlargement, and urinary CT urography was normal. Squamous cell carcinoma antigen levels were within the normal range.

Indexed as

AdenocarcinomaCarcinoma, Squamous CellHuman papillomavirus 18Papillomavirus InfectionsUterine Cervical NeoplasmsFemaleHumansMiddle AgedAadenocarcinomaCase reportCervical cancerHPVSquamous cell carcinoma

Identifiers

PMID40405116
PMCPMC12101027

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.