ArticleBMC ophthalmology2025
Differential diagnostic importance of swept-source optical coherence tomography in ocular surface lesions : Swept-source OCT in ocular surface lesions.
Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe purpose of this retrospective study was to analyze the features of different ocular surface lesions using high resolution swept-source optical coherence tomography (OCT) and to correlate those characteristics with histopathologic alterations.
methodsThirty-eight eyes of 37 patients (19 males and 18 females) were included in this study with a mean age of 60.36 ± 17.29 years years. Anterior segment imaging was performed with a swept-light source OCT system (ANTERION, Heidelberg Engineering, Germany) using the Imaging App. Clinical diagnosis based on the slit-lamp findings was compared with the OCT features of the lesion and the histopathology result.
resultsBased on the OCT features, 11 lesions were in the epithelium, of which 5 had only epithelial component. Six growths had both epithelial and subepithelial components and 27 lesions were confined to the substantia propria. The OCT finding and histopathology result correlated in 57% (6/11) for epithelial involvement and in 84% (28/33) for subepithelial involvement. In 25 cases (65%), the clinical and histopathology diagnosis agreed. In 13 cases (35%), the clinical suspicion was different from the final histopathology diagnosis. Out of those 13 cases, high-resolution OCT findings were suggestive of the histopathology results in 8 cases.
conclusionsHigh-resolution swept-source OCT provided valuable information of the structure, topographic location and extent of an ocular surface lesion and was helpful in assisting the diagnosis.
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