ArticleBMC plant biology2025
Overview of RING gene family in maize (Zea mays L.): ZmRING-93 enhances drought tolerance in transgenic Arabidopsis.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Identification of a Major QTL Controlling Maize Lateral Root Branching Number Through Integrated BSA-Seq and Transcriptome Analysis.International journal of molecular sciences · 2026Article
- Regulatory roles of E3 ubiquitin ligase RNF128 in inflammatory diseases and tumors.Journal of Cancer · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundRING-type E3 ligases are critical regulators of diverse plant processes, yet their roles in maize remain poorly defined, particularly in drought responses. To address this knowledge gap, we conducted an integrative analysis of maize RING genes, combining evolutionary profiling, and candidate-gene association studies to identify drought-associated candidates. Key genes were further characterized via quantitative expression profiling, subcellular localization, in vitro ubiquitination assay, and functional validation in transgenic Arabidopsis. This study aimed to provide new insights into the maize RING gene family's role in drought stress adaptation.
resultsWe employed three distinct methods and identified a total of 590 proteins. Phylogenetic analysis revealed that these proteins could be grouped into 11 separate clusters. Our findings suggested that the expansion of the RING family in maize was likely due to gene duplication events. Notably, genetic variations in ZmRING-93 were significantly associated with drought tolerance, and its expression was up-regulated under various abiotic stress conditions and hormone treatments. We further discovered that ZmRING-93 was a functional ubiquitin E3 ligase that localized to the nucleus, cytoplasm, and parts of the endoplasmic reticulum. Transgenic Arabidopsis plants overexpressing ZmRING-93 exhibited enhanced drought tolerance, with a lower water loss rate, further supporting the importance of ZmRING-93 in drought tolerance.
conclusionsThese findings revealed that ZmRING-93 contributed to drought tolerance in maize and provided a basis for further investigation of the role of RING domain-containing proteins.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.