ArticleBMC infectious diseases2025
Predicting myocardial damage in children with mycoplasma pneumoniae pneumonia: a retrospective case-control study.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neutrophil-to-lymphocyte ratio for predicting disease severity and outcomes in children with Mycoplasma pneumoniae pneumonia: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Association between 23S rRNA gene positivity and clinical characteristics in patients with mycoplasma pneumoniae pneumonia.BMC pediatrics · 2026Article
- Correlation analysis of FABP3, MCP-4, and CXCL9 levels and myocardial damage in patients with severe pneumonia.Journal of medical biochemistry · 2026Article
- Blood-based inflammatory parameters and machine learning models for mortality prediction in critically ill pediatric pneumonia: a retrospective cohort study.Translational pediatrics · 2026Article
- Lung ultrasound radiomics for identifying severeFrontiers in pediatrics · 2026Article
- Development of a nomogram to predict acute liver injury in children withFrontiers in pediatrics · 2026Article
- Evaluation and follow-up of left ventricular function in children with Mycoplasma pneumoniae pneumonia using cardiac magnetic resonance feature tracking.Cardiology journal · 2026Article
- Immunopathogenesis, molecular phenotyping, and host-directed interventions for severe pediatricFrontiers in cellular and infection microbiology · 2026Review
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2 authors.
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Abstract
purposeTo investigate the clinical indicators that can predict myocardial damage in children with mycoplasma pneumoniae pneumonia (MPP) to help early identification and management.
methodsThe clinical data of 123 MPP children admitted from December 2023 to February 2024 in the affiliated Changzhou Children's Hospital of Nantong University were analyzed retrospectively. According to the creatine kinase isoenzyme (CK-MB) level, the children were divided into 61 cases without myocardial damage group and 62 cases with myocardial damage group. Clinical manifestations and laboratory parameters were compared between the two groups. The factors affecting myocardial damage in children with MPP were analyzed by logistic regression. The ROC curve analyzed the predictive value of relevant indicators for myocardial damage in children with MPP.
resultsThe incidence of abnormal electrocardiogram (ECG), extrapulmonary manifestations (except myocardial damage), white blood cell count (WBC), neutrophil/lymphocyte ratio (NLR), erythrocyte sedimentation rate (ESR), albumin and other myocardial enzyme parameters in the myocardial damage group were higher than those in the group without myocardial damage (P < 0.05), and the median age and platelet/neutrophil ratio (PNR) were lower than those in the group without myocardial damage (P < 0.05); there was no significant difference in general data such as gender, duration of fever, length of hospital stay, the incidence of severe pneumonia between the two groups (P > 0.05); multivariate logistic regression analysis showed that median age, NLR level and extrapulmonary manifestations (except myocardial damage) were the main factors affecting myocardial damage in children with MPP (P < 0.05); considering the interaction between NLR and PNR. We also performed ROC curve analysis for PNR. Among the univariate factors, PNR had the highest predictive value, and the specificity was as high as 86.9%. The combined area under the curve of the four indicators was 0.747, higher than that of the univariate factor (P < 0.001), with a predictive sensitivity of 83.9% and a specificity of 63.9%.
conclusionChildren with MPP younger than 6.79 years have extrapulmonary manifestations (acute sinusitis, acute otitis media, etc.), NLR > 2.41, and PNR < 44.74 in blood routine are more likely to develop myocardial damage. CLINICAL TRIAL NUMBER: Not applicable.
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